3
Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
http://sms.cam.ac.uk/collection/1633792
The aim of this sixmonth research programme is to create a unique forum to strengthen and develop research links between stateoftheart experimental "wet" sciences (biology, medicine, biophysics) and theoretical "dry" sciences (pure, applied and computational mathematics, theoretical physics, statistics). In this programme we will discuss and present in a handson format current experimental methodology for cell motility and pattern formation. We will emphasise interactions between experimentalists and theoreticians, with the dual goals of understanding how current mathematical techniques from physics, differential geometry, mathematical modelling and numerical analysis can help to understand current problems in the areas of cell motility and pattern formation, and what new mathematical techniques may emerge in the process.
Read more at http://www.newton.ac.uk/programmes/CGP/
1440
2016
Thu, 26 May 2016 13:53:47 +0100
Tue, 14 Jan 2014 10:09:05 +0000
en
smssupport@ucs.cam.ac.uk
Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
http://sms.cam.ac.uk/collection/1633792
http://rss.sms.cam.ac.uk/itunesimage/1633793.jpg
http://video.search.yahoo.com/mrss
Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
The aim of this sixmonth research programme is to create a unique forum to strengthen and develop research links between stateoftheart experimental "wet" sciences (biology, medicine, biophysics) and theoretical "dry" sciences (pure, applied and computational mathematics, theoretical physics, statistics). In this programme we will discuss and present in a handson format current experimental methodology for cell motility and pattern formation. We will emphasise interactions between experimentalists and theoreticians, with the dual goals of understanding how current mathematical techniques from physics, differential geometry, mathematical modelling and numerical analysis can help to understand current problems in the areas of cell motility and pattern formation, and what new mathematical techniques may emerge in the process.
Read more at http://www.newton.ac.uk/programmes/CGP/
Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
The aim of this sixmonth research programme is to create a unique forum to strengthen and develop research links between stateoftheart experimental "wet" sciences (biology, medicine, biophysics) and theoretical "dry" sciences (pure, applied and computational mathematics, theoretical physics, statistics). In this programme we will discuss and present in a handson format current experimental methodology for cell motility and pattern formation. We will emphasise interactions between experimentalists and theoreticians, with the dual goals of understanding how current mathematical techniques from physics, differential geometry, mathematical modelling and numerical analysis can help to understand current problems in the areas of cell motility and pattern formation, and what new mathematical techniques may emerge in the process.
Read more at http://www.newton.ac.uk/programmes/CGP/
Cambridge University
Sarah Middle
sm828@cam.ac.uk
http://sms.cam.ac.uk/collection/1633792
Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
Sarah Middle
sm828@cam.ac.uk
http://sms.cam.ac.uk/person/sm828
20140114T10:09:05+00:00
INIMS
101092

Mathematical models for cellextracellular matrix interactions in tissue development
ucs_sms_1633792_2078178
http://sms.cam.ac.uk/media/2078178
Mathematical models for cellextracellular matrix interactions in tissue development
Green, E (University of Adelaide)
Wednesday 16th September 2015  13:30 to 14:15
Tue, 29 Sep 2015 17:21:34 +0100
108
108100
Isaac Newton Institute
Green, E
09263cf564ace78fbedf63fc356b7666
e561d4f7d1c56c2e28d6eb73508c0ace
3b2fffb2368ef4c05c566423514d7f56
a7c8d54c46b95dfcee43de90008ccf5f
Green, E (University of Adelaide)
Wednesday 16th September 2015  13:30 to...
Green, E (University of Adelaide)
Wednesday 16th September 2015  13:30 to 14:15
Cambridge University
2812
http://sms.cam.ac.uk/media/2078178
Mathematical models for cellextracellular matrix interactions in tissue development
Green, E (University of Adelaide)
Wednesday 16th September 2015  13:30 to 14:15
Mechanical interactions between cells and the fibrous extracellular matrix (ECM) in which they reside play a key role in tissue development. Mechanical cues from the environment (such as stress, strain and fibre orientation) regulate a range of cell behaviours, including proliferation, differentiation and motility. In turn, the ECM structure is affected by cells exerting forces on the matrix which result in deformation and fibre realignment. We present a mathematical model to investigate this mechanical feedback between cells and the ECM. We consider a threephase mixture of collagen, culture medium and cells, and formulate a system of partial differential equations which represents conservation of mass and momentum for each phase. This modelling framework takes into account the anisotropic mechanical properties of the collagen gel arising from its fibrous microstructure. We also propose a cellcollagen interaction force which depends upon fibre orientation and collagen density. We use a combination of numerical and analytical techniques to study the influence of cellECM interactions on pattern formation in tissues. Our results illustrate the wide range of structures which may be formed, and how those that emerge depend upon the importance of cellECM interactions.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160526T13:53:47+01:00
2812
2078178
true
16x9
false

Sensitivity analysis and quantification of uncertainty
ucs_sms_1633792_2037594
http://sms.cam.ac.uk/media/2037594
Sensitivity analysis and quantification of uncertainty
Gerisch, A (Technische Universität Darmstadt)
Friday 24th July 2015, 09:00 to 10:15
Thu, 30 Jul 2015 13:46:22 +0100
Isaac Newton Institute
Gerisch, A
e8a7d2854653f272831abea8d58ace34
f408e7dd475100374178010abeca5109
e78bee07c39a781a06c894228b1f875f
aac8309173582aaf2470abe269165e5f
Gerisch, A (Technische Universität Darmstadt)
Friday 24th July 2015, 09:00 to...
Gerisch, A (Technische Universität Darmstadt)
Friday 24th July 2015, 09:00 to 10:15
Cambridge University
4860
http://sms.cam.ac.uk/media/2037594
Sensitivity analysis and quantification of uncertainty
Gerisch, A (Technische Universität Darmstadt)
Friday 24th July 2015, 09:00 to 10:15
In this lecture we will review methods for the local and global sensitivity analysis as well as a stochastic collocation approach for the quantification of uncertainty. These techniques can provide additional insight into given models as well as guide future research. However, they also come with their own computational challenges, which will be discussed. The methods are illustrated using some instructive examples from pattern formation.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150730T13:46:22+01:00
4860
2037594
true
16x9
false

$\Sigma^0_3$ determinacy and friends
ucs_sms_1633792_2078157
http://sms.cam.ac.uk/media/2078157
$\Sigma^0_3$ determinacy and friends
Lubarsky, R (Florida Atlantic University)
Tuesday 15th September 2015  15:00 to 16:00
Tue, 06 Oct 2015 14:32:11 +0100
Isaac Newton Institute
Lubarsky, R
752dc2aa7f51c0a0d5e3d54f784553a9
f4045101c51473358fb66da2844a746d
f8890cfbff30794094f74ce298eabc50
dc62ddfd1143eca610e1016e79029872
Lubarsky, R (Florida Atlantic University)
Tuesday 15th September 2015  15:00...
Lubarsky, R (Florida Atlantic University)
Tuesday 15th September 2015  15:00 to 16:00
Cambridge University
3464
http://sms.cam.ac.uk/media/2078157
$\Sigma^0_3$ determinacy and friends
Lubarsky, R (Florida Atlantic University)
Tuesday 15th September 2015  15:00 to 16:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151006T14:32:12+01:00
3464
2078157
true
16x9
false

A brief review of the mathematics and mechanics of biological membranes, plates, and shell
ucs_sms_1633792_2032525
http://sms.cam.ac.uk/media/2032525
A brief review of the mathematics and mechanics of biological membranes, plates, and shell
Goriely, A (University of Oxford)
Friday 17th July 2015, 10:45 to 12:00
Tue, 21 Jul 2015 13:26:55 +0100
Isaac Newton Institute
Goriely, A
a7b770582f6e2b501379e3087629623d
63cf6d9dd5c3a9670da01d15164a4cbc
2615196710d1f4071d64a58ea31ad614
3c332a4539af1ab6c645a8e690192996
Goriely, A (University of Oxford)
Friday 17th July 2015, 10:45 to 12:00
Goriely, A (University of Oxford)
Friday 17th July 2015, 10:45 to 12:00
Cambridge University
4620
http://sms.cam.ac.uk/media/2032525
A brief review of the mathematics and mechanics of biological membranes, plates, and shell
Goriely, A (University of Oxford)
Friday 17th July 2015, 10:45 to 12:00
Many biological structures, such as cellular walls, epithelial sheet, pollen tubes, and seashells can be modelled as twodimensional objects. That is, these structures have a transverse length scale much smaller than the other two typical length scales. In this general lecture, I will review the basic aspects of the mathematics and mechanics of surfaces. I will start by reviewing the differential geometry of surface, then consider classical models for lipid bilayers and their use in cellular biology. I will describe how to model bioelastic membranes, plates, and shells and how to extend classical models to include active and growth processes. I will apply these ideas to microbial filaments, bleb formation, and to urchin and seashell growth.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150721T13:26:55+01:00
4620
2032525
true
16x9
false

A Computational Model for Single Cell Migration and Chemotaxis: Coupling Bulk and Membrane Bound Processes
ucs_sms_1633792_2078164
http://sms.cam.ac.uk/media/2078164
A Computational Model for Single Cell Migration and Chemotaxis: Coupling Bulk and Membrane Bound Processes
Mackenzie, J (University of Strathclyde)
Tuesday 15th September 2015  15:30 to 16:15
Tue, 29 Sep 2015 11:24:18 +0100
Isaac Newton Institute
Mackenzie, J
3f78c468414782c1cae4001cabaced25
fdd55d50f66744a7fcc5d64528063e24
547431b386e12c88cd1e17ec87812cb2
Mackenzie, J (University of Strathclyde)
Tuesday 15th September 2015  15:30...
Mackenzie, J (University of Strathclyde)
Tuesday 15th September 2015  15:30 to 16:15
Cambridge University
2836
http://sms.cam.ac.uk/media/2078164
A Computational Model for Single Cell Migration and Chemotaxis: Coupling Bulk and Membrane Bound Processes
Mackenzie, J (University of Strathclyde)
Tuesday 15th September 2015  15:30 to 16:15
Coauthors: Michael Nolan (University of Strathclyde), Grant McDonald (University of Strathclyde), Matt Neilson (Beatson Institute for Cancer Research), Robert Insall (Beatson Institute for Cancer Research)
In this talk I will present details about a moving mesh finite element method for the approximate solution of partial differential equations on an evolving bulk domain in two dimensions, coupled to the solution of partial differential equations on the evolving domain boundary. Problems of this type occur frequently in the modelling of eukaryotic cell migration and chemotaxis  for these applications the bulk domain is either the intracellular or extracellular region and the domain boundary is the cell membrane. Fundamental to the success of the method is the robust generation of bulk and surface meshes for the evolving domains. For this purpose we use a moving mesh partial differential equation (MMPDE) approach. The developed method is applied to model problems with known solutions which indicate secondorder spatial and temporal accuracy. The method is then applied to a model of the twoway interaction of a migrating cell with an external chemotactic field.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T11:24:18+01:00
2837
2078164
true
16x9
false

A hybrid model to test mechanical cues driving cell migration in angiogenesis
ucs_sms_1633792_2182865
http://sms.cam.ac.uk/media/2182865
A hybrid model to test mechanical cues driving cell migration in angiogenesis
Angélique, S [CNRS (Centre national de la recherche scientifique)]
Tuesday 17th November 2015  11:00 to 12:30
Wed, 17 Feb 2016 15:54:56 +0000
Isaac Newton Institute
Angélique, S
87497485982a9977ff92fe98c0287809
828a14b2c78e3805a9e506fe34ffa568
a2ac507b1a362b99ac008d842a6e8518
d37190280a6b6b8e16ce9b6c53a56b7e
Angélique, S [CNRS (Centre national de la recherche scientifique)]
Tuesday...
Angélique, S [CNRS (Centre national de la recherche scientifique)]
Tuesday 17th November 2015  11:00 to 12:30
Cambridge University
2490
http://sms.cam.ac.uk/media/2182865
A hybrid model to test mechanical cues driving cell migration in angiogenesis
Angélique, S [CNRS (Centre national de la recherche scientifique)]
Tuesday 17th November 2015  11:00 to 12:30
Many studies are stressing the crucial importance of the mechanical component in angiogenesis, but still, very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuousdiscrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum whereas the cells are described as discrete elements.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160217T15:54:56+00:00
2490
2182865
true
16x9
false

A model for selection of eyespots on butterfly wings
ucs_sms_1633792_2083010
http://sms.cam.ac.uk/media/2083010
A model for selection of eyespots on butterfly wings
Sekimura, T
Thursday 3rd September 2015  11:00 to 12:00
Tue, 06 Oct 2015 14:29:10 +0100
Isaac Newton Institute
Sekimura, T
b407275e5897e76ab82b0f3bea49a5f7
02c6f18fa26ead86705e42213437a341
d33d9ed0b45a3f199c282bf8f4d4fe16
42378439f62f0571d4c950bf8abc3e3d
Sekimura, T
Thursday 3rd September 2015  11:00 to 12:00
Sekimura, T
Thursday 3rd September 2015  11:00 to 12:00
Cambridge University
3600
http://sms.cam.ac.uk/media/2083010
A model for selection of eyespots on butterfly wings
Sekimura, T
Thursday 3rd September 2015  11:00 to 12:00
The development of eyespots on the wing surface in butterflies of the Family Nympalidae is one of the most studied examples of biological pattern formation. However, little is known about the mechanism that determines global pattern elements such as the number and precise locations of eyespots on the entire wing. Eyespots develop around signaling centers, called foci of a group of focal cells, that are located equidistant from wing veins along the midline of a wing cell (an area bounded by veins). A fundamental question that remains unsolved is, why a certain wing cell develops an eyespot, while other wing cells do not. We illustrate that the key to understanding focus point selection may be in the venation system of the wing disc. Our main hypothesis is that changes in morphogen concentration along the proximal boundary veins of wing cells govern focus point selection. Based on previous studies, we focus on a spatially twodimensional reactiondiffusion system model posed in the interior of each wing cell that describes the formation of focus points. Using finite element based numerical simulations, we demonstrate that variation in the proximal boundary condition is sufficient to robustly select whether an eyespot focus point forms in otherwise identical wing cells. We also illustrate that this behavior is robust to small perturbations in the parameters and geometry and moderate levels of noise. Hence, we suggest that an anteriorposterior pattern of morphogen concentration along the proximal vein may be the main determinant of the distribution of focus points on the entire wing surface. In order to complete our model, we propose a two stage reactiondiffusion system model, in which an onedimensional surface reactiondiffusion system, posed on the proximal veins, generates the morphogen concentrations that act as nonhomogeneous Dirichlet (i.e., fixed) boundary conditions for the twodimensional reactiondiffusion model posed in the wing cells. The twostage model appears capable of generating focus point distributions observed in nature. We therefore conclude that changes in the proximal boundary conditions are sufficient to explain the empirically observed distribution of eyespot focus points on the entire wing surface. The model predicts, subject to experimental verification, that the source strength of the activator at the proximal boundary should be lower in wing cells in which focus points form than in those that lack focus points.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151006T14:29:10+01:00
3600
2083010
true
16x9
false

A Theoretician's Overview of Some Basic Problems in the Modelling and Analysis of Cell Motility
ucs_sms_1633792_2029292
http://sms.cam.ac.uk/media/2029292
A Theoretician's Overview of Some Basic Problems in the Modelling and Analysis of Cell Motility
Othmer, H (University of Minnesota)
Monday 13th July 2015, 10:45  11:45
Wed, 15 Jul 2015 18:18:25 +0100
Isaac Newton Institute
Othmer, H
27330073525c63e1ad2b525087211c1f
f90ebec69f1ce88e9460bbe1b19f1d2f
a55b96c73d3bd01e35ebc7878c38142e
0d1c2672b0cfa4555235a49d6480d655
Othmer, H (University of Minnesota)
Monday 13th July 2015, 10:45  11:45
Othmer, H (University of Minnesota)
Monday 13th July 2015, 10:45  11:45
Cambridge University
4080
http://sms.cam.ac.uk/media/2029292
A Theoretician's Overview of Some Basic Problems in the Modelling and Analysis of Cell Motility
Othmer, H (University of Minnesota)
Monday 13th July 2015, 10:45  11:45
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:18:25+01:00
4080
2029292
true
16x9
false

Actin cortex mechanics in cell migration without focal adhesions
ucs_sms_1633792_2029299
http://sms.cam.ac.uk/media/2029299
Actin cortex mechanics in cell migration without focal adhesions
Paluch, E
Monday 13th July 2015, 13:30  14:30
Wed, 15 Jul 2015 18:38:37 +0100
Isaac Newton Institute
Paluch, E
bec86438e63b52d795453c040b5a2e83
f2e4eabb3361207d4470ffc412c8e741
ba38a8315e2ced5a09202be420f33b28
0a7e1a410741b99f977cee164f51eb55
Paluch, E
Monday 13th July 2015, 13:30  14:30
Paluch, E
Monday 13th July 2015, 13:30  14:30
Cambridge University
4320
http://sms.cam.ac.uk/media/2029299
Actin cortex mechanics in cell migration without focal adhesions
Paluch, E
Monday 13th July 2015, 13:30  14:30
The shape of animal cells is primarily determined by the cellular cortex, a thin network of actin filaments and myosin motors that lies directly underneath the plasma membrane. Cell shape changes are driven by controlled changes in the physical properties of the cortex, which arise from the microscopic architecture, composition and dynamics of the cortical network. We investigate how the mechanical properties of the cortex are controlled at the molecular level, and how changes in these properties drive cell deformation. We have developed methods to investigate the spatial organisation of the cortex at the microscopic scale and are exploring how network organisation and the spatial distribution of motor proteins determine cortical tension. A precise spatial control of cortex tension and contractility is essential during cell shape changes. For example, during cell migration, contractility gradients towards the back of the cell have been involved in promoting cell polarization and the forward movement of the cell body. We are studying the control and function of cortical contractile tension during blebbased migration of non adherent cells in 3dimensional confinement. We could show that in such cells, a sustained rearward cortical flow is sufficient to drive persistent cell motion in confinement, even in the absence of specific substrate adhesions. We show that the nonadherent cells use a frictionbased migration mechanism, which relies on forces several orders of magnitude smaller than adhesionbased migration. Such focal adhesionindependent locomotion may be advantageous for cells crossing multiple tissues, as it does not require the expression of tissuespecific receptors. Related Links
http://www.ucl.ac.uk/lmcb/researchgroup/ewapaluchresearchgroup  lab website
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:38:37+01:00
4320
2029299
true
16x9
false

Actin dynamics in Dictyostelium
ucs_sms_1633792_2029327
http://sms.cam.ac.uk/media/2029327
Actin dynamics in Dictyostelium
Bretschneider, T (University of Warwick)
Tuesday 14th July 2015, 13:30  14:30
Wed, 15 Jul 2015 18:18:21 +0100
Isaac Newton Institute
Bretschneider, T
8913a6f4c1da60e62a19b7163ca21272
7f5ec3c908b4228cc75d38793395074d
cf0c5fad9804f1907d9b57e86730697a
9aeb99a5e10146b656ef427f5b97f9e7
Bretschneider, T (University of Warwick)
Tuesday 14th July 2015, 13:30  14:30
Bretschneider, T (University of Warwick)
Tuesday 14th July 2015, 13:30  14:30
Cambridge University
3466
http://sms.cam.ac.uk/media/2029327
Actin dynamics in Dictyostelium
Bretschneider, T (University of Warwick)
Tuesday 14th July 2015, 13:30  14:30
Dictyostelium discoideum is one of only ten nonmammalian model organisms for biomedical research officially supported by the NIH. Above all this has to do with Dictyostelium being a genetically very tractable organism in general, but particularly in terms of cell migration, signalling to the actin cytoskeleton is remarkably conserved between Dictyostelium and mammalian leukocytes. Furthermore, few other organisms have been studied so extensively regarding theoretical aspects of cell migration. I will review the biology of signalling to the actin cytoskeleton in Dictyostelium, highlighting the role of selforganisation and excitability of the actin system in the formation of functional dynamic structures in the absence of external signals. I will conclude with recent work on imagebased modelling of cell reorientation and blebbing. Related Links
http://www2.warwick.ac.uk/fac/sci/systemsbiology/staff/bretschneider/publications/  Publications Bretschneider
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:18:21+01:00
3466
2029327
true
16x9
false

Adhesions in epithelial cell migration
ucs_sms_1633792_2030506
http://sms.cam.ac.uk/media/2030506
Adhesions in epithelial cell migration
Leube, R (RWTH Aachen University)
Wednesday 15th July 2015, 15:15 to 16:30
Fri, 17 Jul 2015 18:34:42 +0100
Isaac Newton Institute
Leube, R
fba03898cc8cce7660dadfb51bbc3dcd
cf42b15a8d3015a7a822289b513c5bdc
1b2e0e7e6686598f00eb3162be8c7cbc
cfe3852a389c6f3fb338322b357663ca
Leube, R (RWTH Aachen University)
Wednesday 15th July 2015, 15:15 to 16:30
Leube, R (RWTH Aachen University)
Wednesday 15th July 2015, 15:15 to 16:30
Cambridge University
4560
http://sms.cam.ac.uk/media/2030506
Adhesions in epithelial cell migration
Leube, R (RWTH Aachen University)
Wednesday 15th July 2015, 15:15 to 16:30
Collective cell migration is characteristic for epithelial cells requiring not only reversible attachment to the extracellular matrix but also continued celltocell cohesion of the entire epithelial sheet. The different types of adhesive functions have been linked to morphologically and functionally distinct multimolecular complexes, which physically couple to the cytoskeleton and act as signaling centers. We will first describe the different types of adhesion sites that are characteristically encountered in epithelial tissues and present selected examples of human diseases linked to perturbation of these sites. Emphasis will be on the plasticity of the different junction types and their crosstalk with each other and other cellular elements. Finally, questions regarding modulation and function of the different adhesion modes will be discussed in the context of epithelial cell migration.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:34:42+01:00
4560
2030506
true
16x9
false

An integrated computational approach for the design of patientspecific virtual tumours
ucs_sms_1633792_2140252
http://sms.cam.ac.uk/media/2140252
An integrated computational approach for the design of patientspecific virtual tumours
Stéphanou, A (CNRS (Centre national de la recherche scientifique), Université Joseph Fourier Grenoble)
Monday 7th December 2015  13:30 to 14:15
Mon, 21 Dec 2015 10:11:29 +0000
Isaac Newton Institute
Stéphanou, A
e6db79144a55d630da8fb89023dff596
7f48239319f62d0a68e0551c452cc622
5ea2e3c8f851fbf2af9210e41feb29b0
e8ed6d633fad77cb06748c2c87fb5222
Stéphanou, A (CNRS (Centre national de la recherche scientifique), Université...
Stéphanou, A (CNRS (Centre national de la recherche scientifique), Université Joseph Fourier Grenoble)
Monday 7th December 2015  13:30 to 14:15
Cambridge University
2674
http://sms.cam.ac.uk/media/2140252
An integrated computational approach for the design of patientspecific virtual tumours
Stéphanou, A (CNRS (Centre national de la recherche scientifique), Université Joseph Fourier Grenoble)
Monday 7th December 2015  13:30 to 14:15
The design of a patientspecific virtual tumour is an important step towards personalized medicine since the virtual tumour can be used to define the most adapted and efficient treatment protocol. However this requires to capture the description of many key events of tumour development, including angiogenesis, matrix remodelling, hypoxia, cell heterogeneity that will all influence the tumour growth kinetics and degree of tumour invasiveness. To that end, an integrated hybrid and multiscale approach has been developed based on data acquired on a preclinical mouse model as a proof of concept. Fluorescence imaging is exploited to build casespecific virtual tumours and to validate their spatiotemporal evolution. The validity of the model will be discussed as well as its potential to identify the best therapeutic strategy for each individual tumour case.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:11:29+00:00
2674
2140252
true
16x9
false

Analysis of stochastic multiscale systems: derivation of coarsegrained models, calculation of effective coefficients and data driven approaches.
ucs_sms_1633792_2033218
http://sms.cam.ac.uk/media/2033218
Analysis of stochastic multiscale systems: derivation of coarsegrained models, calculation of effective coefficients and data driven approaches.
Pavliotis, G (Imperial College London)
Monday 20th July 2015, 10:45 to 12:00
Wed, 22 Jul 2015 16:49:20 +0100
Isaac Newton Institute
Pavliotis, G
434cd75a8d522cdd047bbc2adbec27f7
c9af49ec50116b53cd23b0fe3a1de911
914d59aba19987678b9504610564f3e9
bd09008403a560d1c7f1a0fe53c01921
Pavliotis, G (Imperial College London)
Monday 20th July 2015, 10:45 to 12:00
Pavliotis, G (Imperial College London)
Monday 20th July 2015, 10:45 to 12:00
Cambridge University
4440
http://sms.cam.ac.uk/media/2033218
Analysis of stochastic multiscale systems: derivation of coarsegrained models, calculation of effective coefficients and data driven approaches.
Pavliotis, G (Imperial College London)
Monday 20th July 2015, 10:45 to 12:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150722T16:49:20+01:00
4440
2033218
true
16x9
false

Anomalous diffusion is everywhere but where?
ucs_sms_1633792_2090908
http://sms.cam.ac.uk/media/2090908
Anomalous diffusion is everywhere but where?
Korabel, M (University of Manchester)
Thursday 15th October 2015  11:00 to 12:00
Fri, 16 Oct 2015 17:07:00 +0100
Isaac Newton Institute
Korabel, M
2e418768d54fe5857fcfbcafd64d99cb
e2c26223572a4b48ec1956673b335588
bdbd1d708bd89c5a6f295963c81ba984
13db4b3da53794164d9fcd8a166e3fd3
Korabel, M (University of Manchester)
Thursday 15th October 2015  11:00 to...
Korabel, M (University of Manchester)
Thursday 15th October 2015  11:00 to 12:00
Cambridge University
3840
http://sms.cam.ac.uk/media/2090908
Anomalous diffusion is everywhere but where?
Korabel, M (University of Manchester)
Thursday 15th October 2015  11:00 to 12:00
It has become clear that anomalous diffusion is as widespread and important as normal diffusion. However, in biological systems anomalous diffusion is usually observed as a transient before transition to normal diffusion. In my talk I will describe an approach to nonlinear and nonMarkovian generalization of two popular models of anomalous diffusion: subdiffusive continuous time random walk and superdiffusive Levy walk model. This approach easily allows to take into account external forces and interactions between random walkers. More importantly, we show that external forces and interactions lead to the transition to seemingly normal diffusion. This may lead to a wrong conclusion in analyses of experimental results on transient subdiffusion. Contrary to normal diffusion, the properties of the process remain to depend on anomalous exponent.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151016T17:07:00+01:00
3840
2090908
true
16x9
false

Cancer Cell Migration in 3D
ucs_sms_1633792_2078100
http://sms.cam.ac.uk/media/2078100
Cancer Cell Migration in 3D
Wirtz, D (Johns Hopkins University)
Tuesday 15th September 2015  09:00 to 10:00
Wed, 30 Sep 2015 09:52:23 +0100
Isaac Newton Institute
Wirtz, D
16146dece60d6c9aebc81cbfcad526c1
dc14a24997f42d426932b8aef8da36f6
eab55eabf0634674f6306a65e57d8224
dff8032e90120bd04bbf578ba305e564
Wirtz, D (Johns Hopkins University)
Tuesday 15th September 2015  09:00 to...
Wirtz, D (Johns Hopkins University)
Tuesday 15th September 2015  09:00 to 10:00
Cambridge University
4080
http://sms.cam.ac.uk/media/2078100
Cancer Cell Migration in 3D
Wirtz, D (Johns Hopkins University)
Tuesday 15th September 2015  09:00 to 10:00
Twodimensional (2D) in vitro culture systems have for a number of years provided a controlled and versatile environment for mechanistic studies of cell adhesion, polarization, and migration, three interrelated cell functions critical to cancer metastasis. However, the organization and functions of focal adhesion proteins, protrusion machinery, and microtubulebased polarization in cells embedded in physiologically more relevant 3D extracellular matrices is qualitatively different from their organization and functions on conventional 2D planar substrates. This talk will describe the implications of the dependence of cell migratory patterns, protrusion generation, force generation, and cell mechanics on 3D settings.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150930T09:52:23+01:00
4080
2078100
true
16x9
false

Case Studies in Cancer Modelling
ucs_sms_1633792_2140457
http://sms.cam.ac.uk/media/2140457
Case Studies in Cancer Modelling
Chaplain, M (University of St Andrews)
Wednesday 9th December 2015  13:45 to 14:30
Mon, 21 Dec 2015 11:05:00 +0000
Isaac Newton Institute
Chaplain, M
fa9901341e8b9b90d5c6958c26e5dd26
915e5b6c7f1a0a8199150a26b5e607ec
f11886d6ba011d0896a271caa78e2239
92c1f6c6d6fbcce397d2f9ff9b5aa431
Chaplain, M (University of St Andrews)
Wednesday 9th December 2015  13:45 to...
Chaplain, M (University of St Andrews)
Wednesday 9th December 2015  13:45 to 14:30
Cambridge University
2973
http://sms.cam.ac.uk/media/2140457
Case Studies in Cancer Modelling
Chaplain, M (University of St Andrews)
Wednesday 9th December 2015  13:45 to 14:30
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:05:01+00:00
2973
2140457
true
16x9
false

Case studies in modelling pattern formation
ucs_sms_1633792_2033211
http://sms.cam.ac.uk/media/2033211
Case studies in modelling pattern formation
Maini, P (University of Oxford)
Monday 20th July 2015, 09:00 to 10:15
Wed, 22 Jul 2015 16:45:24 +0100
Isaac Newton Institute
Maini, P
b9460b805a53fb10bde05f09756cf07c
fd7682657e985719e259525b479069a2
e0d581ee8b553c6723dd8c988ae1713f
cf005cb14aac0cd0b8763e3db5dea307
Maini, P (University of Oxford)
Monday 20th July 2015, 09:00 to 10:15
Maini, P (University of Oxford)
Monday 20th July 2015, 09:00 to 10:15
Cambridge University
4440
http://sms.cam.ac.uk/media/2033211
Case studies in modelling pattern formation
Maini, P (University of Oxford)
Monday 20th July 2015, 09:00 to 10:15
The generation of spatial pattern formation is still a largely unresolved problem in biology. Here we will review some classical models for pattern formation, including the Turing reaction diffusion model, models for chemotaxis, in the context of biological applications.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150722T16:45:24+01:00
4440
2033211
true
16x9
false

Cell Adhesion Video Clip
ucs_sms_1633792_1633797
http://sms.cam.ac.uk/media/1633797
Cell Adhesion Video Clip
Tue, 14 Jan 2014 10:27:41 +0000
Isaac Newton Institute
Anotida Madzvamuse
3c76ded633749b2efb4a1baf3ae6f903
c488c6f14fba1415fa4e12c95f47aab2
3b4c12baff86ad15ee7cf7cc8a155aeb
Cambridge University
18
http://sms.cam.ac.uk/media/1633797
Cell Adhesion Video Clip
Sarah Middle
http://sms.cam.ac.uk/person/sm828
20140117T11:07:17+00:00
18
1633797
true
4x3
false

Cell Migration Assays
ucs_sms_1633792_2034597
http://sms.cam.ac.uk/media/2034597
Cell Migration Assays
Zeno von Guttenberg
Thursday 23rd July 2015, 13:30 to 14:45
Fri, 24 Jul 2015 15:25:59 +0100
Isaac Newton Institute
Zeno von Guttenberg
9bd11b64b2f9a38e6af63ef6b7e7983e
7100609c574ba7fe23afb97fefd07fd1
d8376146b25c3f2710f914e22ece676c
6b086fceb45d80f020a9af61d7fd499b
Zeno von Guttenberg
Thursday 23rd July 2015, 13:30 to 14:45
Zeno von Guttenberg
Thursday 23rd July 2015, 13:30 to 14:45
Cambridge University
4440
http://sms.cam.ac.uk/media/2034597
Cell Migration Assays
Zeno von Guttenberg
Thursday 23rd July 2015, 13:30 to 14:45
The movement of cells between different points induced by certain events, biological signals or environmental inputs is called cell migration. This process is essential for a large number of physiological processes like wound healing and immune response, but also for a variety of diseases. Investigating for instance the migration and invasion of tumor and stromal cells to understand the basic principles, gives valuable input for novel approaches in the diagnosis of cancer, the prognosis and the development of new drugs. Key features of migration assays are the easy application, the reproducibility and the significance of the results. An overview is given about different established in vitro assay types which can be used to evaluate cell migration. The assays are divided in methods for kinetic analysis and for endpoint measurements and also in 2D and 3D migration. Problems and limitations are discussed and the respective read out as well as the mathematical interpretation is presented.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:25:59+01:00
4440
2034597
true
16x9
false

Cell Motility and Signalling to the Cytoskeleton
ucs_sms_1633792_2030534
http://sms.cam.ac.uk/media/2030534
Cell Motility and Signalling to the Cytoskeleton
Ridley, A (King's College London)
Thursday 16th July 2015, 15:15 to 16:30
Fri, 17 Jul 2015 18:35:58 +0100
Isaac Newton Institute
Ridley, A
1d70e23171e551cc2df9166cee31b39b
50764fd8842c3d733328985b0630277b
97a4a297b43e24b2ecfe93c545414188
795985280a3472b8741229e8af8dd531
Ridley, A (King's College London)
Thursday 16th July 2015, 15:15 to 16:30
Ridley, A (King's College London)
Thursday 16th July 2015, 15:15 to 16:30
Cambridge University
4140
http://sms.cam.ac.uk/media/2030534
Cell Motility and Signalling to the Cytoskeleton
Ridley, A (King's College London)
Thursday 16th July 2015, 15:15 to 16:30
Cells move in response to extracellular cues in their environment. Cell motility is driven by the cytoskeleton, principally actin filaments and microtubules. Rho family GTPases are intracellular signal transducers that coordinate cell motility through their effects on the cytoskeleton and cell adhesions. Most of the 20 human Rho GTPases cycle between a GTPbound active form and a GDPbound inactive form, although RhoH and Rnd proteins are constitutively GTPbound. Rho GTPases are activated in response to a wide variety of extracellular cues. Rho GTPases are regulated by and activate a complex network of proteins, including protein kinases, which lead to changes in cytoskeletal dynamics and cell contractility. I will describe results of RNAi screens we have carried out of Rho GTPase network components, including new links between Rho family members and protein kinases.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:35:58+01:00
4140
2030534
true
16x9
false

Cellbased modelling for wound contraction and angiogenesis
ucs_sms_1633792_2108191
http://sms.cam.ac.uk/media/2108191
Cellbased modelling for wound contraction and angiogenesis
Vermolen, F (Delft University of Technology)
Tuesday 3rd November 2015  11:00 to 12:00
Wed, 11 Nov 2015 11:10:02 +0000
Isaac Newton Institute
Vermolen, F
03a6c5fdd4edc0ea4615a252723d7925
f2338a2ddecb131b40e3b2a988318fe6
3cd74adfc1f3c745ed4c5e65d64d5214
97a01c9d89e67e32f0fcc334db44e847
Vermolen, F (Delft University of Technology)
Tuesday 3rd November 2015  11:00...
Vermolen, F (Delft University of Technology)
Tuesday 3rd November 2015  11:00 to 12:00
Cambridge University
4860
http://sms.cam.ac.uk/media/2108191
Cellbased modelling for wound contraction and angiogenesis
Vermolen, F (Delft University of Technology)
Tuesday 3rd November 2015  11:00 to 12:00
Wound contraction and angiogenesis are biological processes that often take place during healing of wounds and in tumor development. To model these processes, one distinguishes between different types of models, which are descriptive at several scales, ranging from cellular scale (microscale) to the tissue scale (macroscale). The models are on the macroscale are based on continuum hypotheses, which means that one sets up and solves partial differential equations with the associated boundary and initial conditions. On the smallest scale one models all kinds of cell phenomena on a molecular level. In this talk, we will consider colonies of cells, which are treated as discrete entities, as well as chemical and mechanical signals that are modelled as sets of partial differential equations. Hence, the current approach is a hybride one.
The process of angiogenesis, which is the formation of a vascular network in tissues, is often modeled by using principles based on cell densities in a continuum approach or on hybride cellularcontinuum level where one uses cellular automata (in particular cellular Potts) models. In this study, we abandon the lattice needed to model the cell positions in cellular automata modelling and instead, we apply a continuous cellbased approach to simulate threedimensional angiogenesis. Next to the application of this modelling strategy to angiogenesis, we discuss the application of the formalism to wound contraction.
The talk will describe some of the mathematical issues encountered in these models and further some animations will be shown to illustrate the potential merits of our approaches.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151111T11:10:02+00:00
4860
2108191
true
16x9
false

CellBased Modelling of Wound Contraction, the Immune System and Angiogenesis
ucs_sms_1633792_2140286
http://sms.cam.ac.uk/media/2140286
CellBased Modelling of Wound Contraction, the Immune System and Angiogenesis
Vermolen, F (Delft University of Technology)
Tuesday 8th December 2015  11:30 to 12:30
Mon, 21 Dec 2015 10:32:15 +0000
Isaac Newton Institute
Vermolen, F
9c34c953f1b71d7f177106511d96a55f
7ceb777e59933aea2a0faecaaaf1d147
b1eedadf889d335fcb03ac17bb025098
d1d3ee3f5e40807a27c400055da8905e
Vermolen, F (Delft University of Technology)
Tuesday 8th December 2015  11:30...
Vermolen, F (Delft University of Technology)
Tuesday 8th December 2015  11:30 to 12:30
Cambridge University
3720
http://sms.cam.ac.uk/media/2140286
CellBased Modelling of Wound Contraction, the Immune System and Angiogenesis
Vermolen, F (Delft University of Technology)
Tuesday 8th December 2015  11:30 to 12:30
Wound contraction and angiogenesis are biological processes that often take place during healing of wounds and in tumor development. To model these processes, one distinguishes between different types of models, which are descriptive at several scales, ranging from cellular scale (microscale) to the tissue scale (macroscale). The models are on the macroscale are based on continuum hypotheses, which means that one sets up and solves partial differential equations with the associated boundary and initial conditions. On the smallest scale one models all kinds of cell phenomena on a molecular level. In this talk, we will consider colonies of cells, which are treated as discrete entities, as well as chemical and mechanical signals that are modelled as sets of partial differential equations. Hence, the current approach is a hybride one.
The process of angiogenesis, which is the formation of a vascular network in tissues, is often modeled by using principles based on cell densities in a continuum approach or on hybride cellularcontinuum level where one uses cellular automata (in particular cellular Potts) models. In this study, we abandon the lattice needed to model the cell positions in cellular automata modelling and instead, we apply a continuous cellbased approach to simulate threedimensional angiogenesis. Next to the application of this modelling strategy to angiogenesis, we discuss the application of the formalism to wound contraction.
Next to angiogenesis, a cell deformation and migration model will be presented, where the cell boundary, as well as the boundary of the nucleus is divided into a set of discrete points. Cell migration is modelled in terms of random walk and chemotaxis. The deformation of the nucleus is a novel step in literature.
The talk will describe some of the mathematical issues encountered in these models and further some animations will be shown to illustrate the potential merits of our approaches.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:32:15+00:00
3720
2140286
true
16x9
false

Cells and embryos as flowing shells: analytical and numerical approaches for viscoelastic liquid shells
ucs_sms_1633792_2140766
http://sms.cam.ac.uk/media/2140766
Cells and embryos as flowing shells: analytical and numerical approaches for viscoelastic liquid shells
Etienne, J (CNRS (Centre national de la recherche scientifique), Université de Grenoble)
Friday 11th December 2015  15:30 to 16:15
Mon, 21 Dec 2015 11:31:36 +0000
Isaac Newton Institute
Etienne, J
78f31a4fd7a4f7cd0ab189511697c8d2
ee06b4f40d7b8e6e729996b27e034880
14ef87fb972537fb7b1273ea9881ddd5
9f0bad5f663120733f3814052fb855b0
Etienne, J (CNRS (Centre national de la recherche scientifique), Université de...
Etienne, J (CNRS (Centre national de la recherche scientifique), Université de Grenoble)
Friday 11th December 2015  15:30 to 16:15
Cambridge University
2882
http://sms.cam.ac.uk/media/2140766
Cells and embryos as flowing shells: analytical and numerical approaches for viscoelastic liquid shells
Etienne, J (CNRS (Centre national de la recherche scientifique), Université de Grenoble)
Friday 11th December 2015  15:30 to 16:15
Actomyosin networks are known to be much denser at external surfaces of cells and early embryos than in their bulk. They are also known to be the major mechanical element allowing the cell to maintain its shape and governing its dynamics: myosin molecular motors convert biochemical energy into mechanical action, which can resolve in increased tension or deformation depending on boundary conditions [1].
Similarly, during early morphogenesis of embryos, actomyosin forms a surfacic continuum, seamed at cellcell boundaries by so called adherens junctions, over a thikness of less than a micron at the outer surface of the 50 micron ellipsoidal embryo. Gene expression is known to lead to successive patternings of myosin density within this actomyosin continuum, which in turn is necessary for the large morphogenetic movements of early embryogenesis to occur. However, while we know that such a myosin patternings are causal, the mechanism by which they govern the correct morphogenetic flows remains unclear. Decyphering it necessitates to resolve the mechanical balance of the embryo with the myosin forceproduction as a source term.
After presenting the general problem in a closed form suitable for mathematical analysis, I will present three particular cases:
 Single cells in a liquid bridgelike geometry, allowing a partial analytical resolution of the viscoelastic mechanical problem.
 Ventral furrow formation of the Drosophila embryo, for which elasticity approaches are possible at short times.
 The surface flow during germband extension of Drosophila, for which we have developped a new surface finite element technique allowing us to solve compressible Stokeslike problems in which velocities are tangential to a curved surface.
[1] J. Étienne, J. Fouchard, D. Mitrossilis, N. Bufi, P. DurandSmet and A. Asnacios, 2015. Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex. Proc. Natl. Acad. Sci. USA 112(9):2740–2745.
Related Links
http://wwwliphy.ujfgrenoble.fr/pagesperso/etienne/  J Etienne's webpage
http://www.newton.ac.uk/seminar/20150918100011001  Talk about the biophysical modelling that is used in this work
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:31:36+00:00
2882
2140766
true
16x9
false

Cellular blebs: pressuredriven, axisymmetric, membrane protrusions
ucs_sms_1633792_2078143
http://sms.cam.ac.uk/media/2078143
Cellular blebs: pressuredriven, axisymmetric, membrane protrusions
Woolley, T (University of Oxford)
Tuesday 15th September 2015  13:30 to 14:15
Tue, 29 Sep 2015 11:14:17 +0100
Isaac Newton Institute
Woolley, T
226caaf8fa2d4e573b8a7ce9af3971c7
e72e7832cfb02e1a7890ec24c5e07f28
8d985820318f3808939951d6adab8fda
Woolley, T (University of Oxford)
Tuesday 15th September 2015  13:30 to 14:15
Woolley, T (University of Oxford)
Tuesday 15th September 2015  13:30 to 14:15
Cambridge University
2900
http://sms.cam.ac.uk/media/2078143
Cellular blebs: pressuredriven, axisymmetric, membrane protrusions
Woolley, T (University of Oxford)
Tuesday 15th September 2015  13:30 to 14:15
Human muscle undergoes an agerelated loss in mass and function. Preservation of muscle mass depends, in part, on stem cells, which navigate along muscle fibres in order to repair damage. Critically, these stem cells have been observed to undergo a new type of motion that uses cell protrusions known as “blebs”, which protrude from the cell and permit it to squeeze in between surrounding material.
By solving the diffusion equation in polar coordinates we have mathematically investigated this blebbing phenomenon with a particular focus on characterizing the effect of age on cell migration. Our results have then been fitted to experimental data allowing us demonstrate that young cells move in a random ‘‘memoryless’’ manner, whereas old cells demonstrate highly directed motion, which would inhibit the chances of a cell finding and repairing damaged tissue.
Further, we have constructed a mechanical model for the problem of pressuredriven blebs based on force and moment balances of an axisymmetric shell. Through investigating multiple extensions of this model we find numerous results concerning size, shape and limiting factors of blebs. Finally, leading us to consider much simpler equations which allow us to connect motion to mechanical properties of the cell, thus, coming full circle in our research.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T11:14:17+01:00
2900
2078143
true
16x9
false

Cellular patterning in plant roots
ucs_sms_1633792_2078394
http://sms.cam.ac.uk/media/2078394
Cellular patterning in plant roots
King, J (University of Nottingham)
Friday 18th September 2015  15:30 to 16:15
Tue, 29 Sep 2015 17:07:55 +0100
Isaac Newton Institute
King, J
bbf229cf40007f9dd2f30e8b8f42b8f7
3366eb47eb54018616585eda1729984e
e26d7f0bcd9f8537c829e7c598eaaa57
2f3aedc5a9a007aedce29e23f096233f
King, J (University of Nottingham)
Friday 18th September 2015  15:30 to 16:15
King, J (University of Nottingham)
Friday 18th September 2015  15:30 to 16:15
Cambridge University
2420
http://sms.cam.ac.uk/media/2078394
Cellular patterning in plant roots
King, J (University of Nottingham)
Friday 18th September 2015  15:30 to 16:15
Coauthors: Anthony Bishopp (University of Nottingham), Nathan Mellor (University of Nottingham), Daniele Muraro (University of Nottingham), Leah Band (University of Nottingham)
Multicellular organisms comprise many different and highly specialized cell types arranged in specific patterns in space and time. The formation of pattern is encoded in genetic and environmental responses. All multicellular organisms start as a single cell. This cell and its daughter cells divide to produce new cells. These divisions are highly orchestrated and both division and growth occur asymmetrically.Plant cells are locked into place by substantial cell walls. All these cells have the same genetic information and positional cues are required to assign specific identities to cells in defined positions. Roots provide an ideal system to investigate cellular pattern as cells are arranged in welldefined lineages extending out of an organised centre.During embryogenesis, cells in the embryonic root are arranged in a radially symmetric pattern of concentric rings. However, as the seedling grows new cell fates (xylem and phloem) are assigned in the central part of the root to transport water and nutrients throughout the plants. The differentiation of these transporting cells represents a crude symmetry breakage with a shift from radial to bisymmetry (two planes of symmetry at 90º to each other).A network of interactions able to produce this symmetry break will be presented. Experimental evidence demonstrating the involvement of these components will be presented and a mathematical model that predicts how these components act in space and time to produce pattern will be described. How this network can be manipulated to produce alternative patterns will also be noted.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T17:07:55+01:00
2420
2078394
true
16x9
false

Chemomechanical modeling of morphogenesis in living matter
ucs_sms_1633792_2140550
http://sms.cam.ac.uk/media/2140550
Chemomechanical modeling of morphogenesis in living matter
Ciarletta, P (Politecnico di Milano)
Thursday 10th December 2015  14:15 to 15:00
Mon, 21 Dec 2015 11:18:22 +0000
Isaac Newton Institute
Ciarletta, P
7905e0ba71da3fd33e6a98bb5854c714
600352a658f39ebbe563b8ff60695a46
3110143902a4412b147a2a26420c9a6e
f157ed70082c1e7529bbde1ba0cd715e
Ciarletta, P (Politecnico di Milano)
Thursday 10th December 2015  14:15 to...
Ciarletta, P (Politecnico di Milano)
Thursday 10th December 2015  14:15 to 15:00
Cambridge University
2640
http://sms.cam.ac.uk/media/2140550
Chemomechanical modeling of morphogenesis in living matter
Ciarletta, P (Politecnico di Milano)
Thursday 10th December 2015  14:15 to 15:00
Life phenomena result from the mutual equilibrium between the living matter and the surrounding media. A network of servomechanisms physiologically restores the stable equilibrium between the interior matter of a living entity in the face of external perturbative agents. In particular, living cells can balance exogenous and endogenous forces using an iterative process, also known as mechanoreciprocity. Hence, not only living matter can adapt through epigenetic remodelling to the external physical cues, but it can also respond by activating gene regulatory processes, which may also drive the onset of pathologies, e.g. solid tumours. Moreover, living materials have the striking ability to change actively their microstructural organization in order to adjust their functions to the surrounding media, developing a state of internal tension, which even persists after the removal of any external loading. This complex mechanical and biochemical interaction can finally control morp hogenesis during growth and remodelling, leading to shape instabilities characterized by a complex morphological phase diagram. In this lecture, I will introduce few mathematical s of mechanobiology and morphogenesis in living materials [1,2], with several applications concerning solid tumours [3], gastrointestinal organogenesis [4], bacterial colonies [5] and nerve fibers [6]. [1] Ciarletta P, Ambrosi D, Maugin G A, Preziosi L. THE EUROPEAN PHYSICAL JOURNAL. E, SOFT MATTER, 2013, 36, 2328. [2] Ciarletta P, Preziosi L, Maugin GA. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 2013, 61, 852872; [3] Ciarletta P. Buckling instability in growing tumour spheroids. PHYSICAL REVIEW LETTERS, 2013, 110. [4] Ciarletta P., Balbi V., Kuhl, E. Pattern selection in growing tubular tissues. PHYSICAL REVIEW LETTERS, 2014, 113, 248101. [5] Giverso, C., Verani M., Ciarletta P. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2015, 12 [6] Taffetani M., Ciarletta P, PHYSICAL REVIEW E, 2015,91
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:18:22+00:00
2640
2140550
true
16x9
false

Colonial patterns formed by chemotactic bacteria E. coli
ucs_sms_1633792_2034576
http://sms.cam.ac.uk/media/2034576
Colonial patterns formed by chemotactic bacteria E. coli
Mimura, M (Meiji University)
Wednesday 22nd July 2015, 13:30 to 14:45
Fri, 24 Jul 2015 15:18:08 +0100
Isaac Newton Institute
Mimura, M
1b9670cea7fca1e6006ecb2f1569affb
3a271eaab13cea8fa09c68199a8fe877
d0fab7f3d9bf8977156012f171b4d9ad
a1b1c6105de02bfbcfbf4198b3389ca2
Mimura, M (Meiji University)
Wednesday 22nd July 2015, 13:30 to 14:45
Mimura, M (Meiji University)
Wednesday 22nd July 2015, 13:30 to 14:45
Cambridge University
4620
http://sms.cam.ac.uk/media/2034576
Colonial patterns formed by chemotactic bacteria E. coli
Mimura, M (Meiji University)
Wednesday 22nd July 2015, 13:30 to 14:45
Over the past ten years, our understanding of how spatiotemporal patterns in far from equilibrium systems has been gradually deepened. Collaborative research of experimental and theoretical works have discovered the mechanism how complex patterns were generated in biological systems. It is emphasized that genetics does not always reveal the occurrence of such patterns and even simple systems may generate ordered as well as chaotic patterns in a selforganized way. As an example, Budrene and Berg observed that chemotactic bacteria of E. coli produce regulated as well as complex colonial patterns., depending on initial concentration of nutrients, In particular, flowerlike patterns called “chevron pattern” is interesting ([1], [2]). Budrene and Berg concluded that such patterns are produced in a selforganized way. Motivated by their conclusion, we propose a macroscopic PDE model and Budrene and Berg understand the mechanism behind such colonial patterns ([3], [4], [5]).
Keywords: colonial pattern formation, chemotactic mobility, selforganization.
REFERENCES [1] Budrene E. O and Berg, H. C.: Complex patterns formed by motile cells of Escherichia coli., Nature 349 pp.630~633 (1991) [2] Budrene E. O and Berg, H. C.: Dynamics of formation of symmetrical patterns by chemotactic bacteria, Nature 376 pp. 49~53 (1995 [3] Aotani A., Mimura M. and Mollee T.: A modelaided understanding of spot pattern formation in chemotactic E. coli colonies, Japan J. Industrial and Applied Mathematics, 27, 522 (2010) [4] Celinski, R., Hilhorst D., Karch G. and Mimura M.: Mathematical properties of solutions to the model of formation of chemotactic E. coli. colonies, manuscript [5] Aotani A. and Mimura M.: Chevron patterns in chemotactic E. coli. colonies, in preparation
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:18:08+01:00
4620
2034576
true
16x9
false

Computational methods for tissue and tumor growth
ucs_sms_1633792_2037601
http://sms.cam.ac.uk/media/2037601
Computational methods for tissue and tumor growth
Lowengrub, J (University of California, Irvine)
Friday 24th July 2015, 10:45 to 12:00
Thu, 30 Jul 2015 13:52:54 +0100
Isaac Newton Institute
Lowengrub, J
5744503fb714e6104f21635c979de536
ec4af9cf71049a5982d529fee40d9571
eaae8a86a3db15a20fca9875f1b09e6b
ba345dafebd06651b2727a33f20d0e80
Lowengrub, J (University of California, Irvine)
Friday 24th July 2015, 10:45...
Lowengrub, J (University of California, Irvine)
Friday 24th July 2015, 10:45 to 12:00
Cambridge University
5460
http://sms.cam.ac.uk/media/2037601
Computational methods for tissue and tumor growth
Lowengrub, J (University of California, Irvine)
Friday 24th July 2015, 10:45 to 12:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150807T12:13:37+01:00
5460
2037601
true
16x9
false

Continuum models for motile cells in shear flow
ucs_sms_1633792_2140300
http://sms.cam.ac.uk/media/2140300
Continuum models for motile cells in shear flow
Bearon, R (University of Liverpool)
Tuesday 8th December 2015  16:15 to 17:00
Mon, 21 Dec 2015 10:28:50 +0000
Isaac Newton Institute
Bearon, R
ac63e1eae98914be62facd4b7a317631
d743e66d17e51e3ec55036bc75753e32
203598cc9841dbdd21ec101c2034717c
063978985da05f60cce55e293e6015a2
Bearon, R (University of Liverpool)
Tuesday 8th December 2015  16:15 to 17:00
Bearon, R (University of Liverpool)
Tuesday 8th December 2015  16:15 to 17:00
Cambridge University
2759
http://sms.cam.ac.uk/media/2140300
Continuum models for motile cells in shear flow
Bearon, R (University of Liverpool)
Tuesday 8th December 2015  16:15 to 17:00
Many microorganisms such as bacteria and algae swim in fluid environments. This swimming behaviour can interact with fluid motions to generate transport which differs both from that experienced by passive tracers in flow and microswimmers in the absence of flow. I will give examples of how populationlevel models can be derived to describe the spatiotemporal distribution of such swimmers, including a model for slender bacteria which undergo runandtumble chemotaxis in a channel (Bearon et al J. Fluid Mech. 2015). The continuum model developed can describe an experimentally observed phenomenon of trapping in high shear which existing driftdiffusion models are unable to capture.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:28:50+00:00
2759
2140300
true
16x9
false

Design principles of actin lamellipodial treadmill: lessons from the fragment
ucs_sms_1633792_2029313
http://sms.cam.ac.uk/media/2029313
Design principles of actin lamellipodial treadmill: lessons from the fragment
Mogilner, A (University of California, Davis)
Tuesday 14th July 2015, 09:00  10:00
Wed, 15 Jul 2015 18:23:12 +0100
Isaac Newton Institute
Mogilner, A
1f735028eddc7a8214a7ee6a1a3a55a8
5ea95728630c4e81eacefe95eed687fa
e76ebcc4314868ca757a65f98d37de5b
c74f697c38fa39d8d1c6e483d985c12f
Mogilner, A (University of California, Davis)
Tuesday 14th July 2015, 09:00 ...
Mogilner, A (University of California, Davis)
Tuesday 14th July 2015, 09:00  10:00
Cambridge University
3780
http://sms.cam.ac.uk/media/2029313
Design principles of actin lamellipodial treadmill: lessons from the fragment
Mogilner, A (University of California, Davis)
Tuesday 14th July 2015, 09:00  10:00
Coauthors: N Ofer (Technion), D Ben Aroush (Technion), J Allard (UC Irvine), E Abu Shah (Technion), K Keren (Technion)
Actin turnover/treadmill is the central driver of cell migration. Though biochemical players enabling actin treadmill are known, its quantitative understanding is lacking. We focused on lamellipodial fragments form fish keratocytes lacking cell body but retaining the ability to migrate. The geometric simplicity of fragments and the absence of organelles and complex actin structures allowed us to characterize quantitatively the spatial actin organization in motile fragments. We used fluorescent microscopy to measure distributions of actin filaments and monomers, as well as the distributions of barbed ends and pointed ends. We then combined the actin mapping with mathematical modeling and FRAP to understand the organization of the actin turnover and treadmill. We found that more than half of actin is not part of the rapidly turning over Factin network but is a diffusing fraction of oligomers and monomers, most of which is not available for polymerization. Modeling suggests that such organization of the actin treadmill enables diffusion to recycle actin effectively and makes cell migration steady, yet prepared for rapid focused acceleration.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:23:12+01:00
3780
2029313
true
16x9
false

Dynamical Quasicondensation of HardCore Bosons at Finite Momenta
ucs_sms_1633792_2163456
http://sms.cam.ac.uk/media/2163456
Dynamical Quasicondensation of HardCore Bosons at Finite Momenta
Schneider, U (University of Cambridge, LudwigMaximiliansUniversität München, MaxPlanckInstitut für Quantenoptik)
Tuesday 12th January 2016  10:00 to 11:00
Mon, 25 Jan 2016 14:38:39 +0000
Isaac Newton Institute
Schneider, U
bc0665b6f18a46c0099703a3319ed519
6ee50ab1ead30c63a5654527638846c9
9760c49fb991f9ea294bd2ff2c05b095
edefbd2224b46a92e6151d7b19724372
Schneider, U (University of Cambridge, LudwigMaximiliansUniversität München,...
Schneider, U (University of Cambridge, LudwigMaximiliansUniversität München, MaxPlanckInstitut für Quantenoptik)
Tuesday 12th January 2016  10:00 to 11:00
Cambridge University
3322
http://sms.cam.ac.uk/media/2163456
Dynamical Quasicondensation of HardCore Bosons at Finite Momenta
Schneider, U (University of Cambridge, LudwigMaximiliansUniversität München, MaxPlanckInstitut für Quantenoptik)
Tuesday 12th January 2016  10:00 to 11:00
We experimentally study the expansion of initially localized ultracold bosons in homogeneous optical lattices in real and momentum space and find that both dimensionality and interaction strength crucially influence these outofequilibrium dynamics. While the atoms expand ballistically in all integrable limits, deviations from these limits dramatically suppress the expansion and lead to the appearance of almost bimodal realspace density distributions. For strongly interacting bosons, we observe a dimensional crossover of the dynamics from ballistic in the onedimensional hardcore case to diffusive in two dimensions, as well as a similar crossover when higher occupancies are introduced into the system. Studying the same expansion in momentum space, we observe the onset of quasicondensation of expanding hardcore bosons at finite momenta in a high energy farfromequilibrium situation, even though longrange order is usually associated with lowtemperature equilibrium situations. In particular, we observe the emergence of peaks at finite momenta that corresponds to the spontaneous formation of coherence with a phase order that differs from the groundstate order.
Related Links
http://www.manybody.phy.cam.ac.uk/  Group Website
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160125T14:38:40+00:00
3322
2163456
true
16x9
false

Epithelial intermediate filament organisation: Modes of regulation in vitro and in vivo
ucs_sms_1633792_2077023
http://sms.cam.ac.uk/media/2077023
Epithelial intermediate filament organisation: Modes of regulation in vitro and in vivo
Leube, R (RWTH Aachen University)
Monday 14th September 2015  11:30 to 12:30
Mon, 28 Sep 2015 14:59:14 +0100
Isaac Newton Institute
Leube, R
14173b2018f3ab2a5dc32b2c66253ba1
4359be2dcf31cfcd29ac2ee80a31a1ef
31055267872968a98fc7c348112345c4
9ae1f0d70b2a7abeab02fb76cf9e8d82
Leube, R (RWTH Aachen University)
Monday 14th September 2015  11:30 to 12:30
Leube, R (RWTH Aachen University)
Monday 14th September 2015  11:30 to 12:30
Cambridge University
3720
http://sms.cam.ac.uk/media/2077023
Epithelial intermediate filament organisation: Modes of regulation in vitro and in vivo
Leube, R (RWTH Aachen University)
Monday 14th September 2015  11:30 to 12:30
The keratin intermediate filament cytoskeleton is a hallmark feature of epithelial cells. Molecular diversity is the basis of its finely tuned contribution to epithelial mechanics and function. Timelapse analysis has revealed an unexpected degree of continuous restructuring of the keratin scaffold in cultured epithelial cells. Multiple factors including other cytoskeletal filaments, cell adhesion sites and growth factors regulate keratin dynamics in vitro. The mechanisms governing the cell typespecific organisation of the keratin network in living organisms is much less understood. Yet, the polarized distribution of intermediate filaments in simple, onelayered epithelia is conserved from the nematode Caenorhabditis elegans to mammals. The use of recently established fluorescent reporter strains now allows monitoring and elucidating intermediate filament morphogenesis in vital tissues and organisms.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150928T14:59:14+01:00
3720
2077023
true
16x9
false

Epithelial morphogenesis in zebrafish gastrulation
ucs_sms_1633792_2078171
http://sms.cam.ac.uk/media/2078171
Epithelial morphogenesis in zebrafish gastrulation
Heisenberg, CP (IST Austria)
Wednesday 16th September 2015  09:00 to 10:00
Tue, 29 Sep 2015 15:34:08 +0100
Isaac Newton Institute
Heisenberg, CP
17f072d46f1efe6d54935e9aff8fcfff
b09758936560a1849890d639c7db5392
e9f97a429aaca4c0d9b2b37a89bf05df
f38a2e463022b3fcf8fd45da9dba5fc1
Heisenberg, CP (IST Austria)
Wednesday 16th September 2015  09:00 to 10:00
Heisenberg, CP (IST Austria)
Wednesday 16th September 2015  09:00 to 10:00
Cambridge University
4080
http://sms.cam.ac.uk/media/2078171
Epithelial morphogenesis in zebrafish gastrulation
Heisenberg, CP (IST Austria)
Wednesday 16th September 2015  09:00 to 10:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T15:34:08+01:00
4080
2078171
true
16x9
false

Filament Based Lamellipodium Model (FBLM) modeling and numerical simulations
ucs_sms_1633792_2140293
http://sms.cam.ac.uk/media/2140293
Filament Based Lamellipodium Model (FBLM) modeling and numerical simulations
Sfakianakis, N (Johannes GutenbergUniversität Mainz)
Tuesday 8th December 2015  14:15 to 15:00
Mon, 21 Dec 2015 10:28:28 +0000
Isaac Newton Institute
Sfakianakis, N
e11a209912190ed30760f33e5646dc65
e96cbfda3ba6575a670d866f2814add8
e280116a5f7375eabcbcf11e416ccca0
13bdff3fea0eec6bf84cd28599002cdd
Sfakianakis, N (Johannes GutenbergUniversität Mainz)
Tuesday 8th December...
Sfakianakis, N (Johannes GutenbergUniversität Mainz)
Tuesday 8th December 2015  14:15 to 15:00
Cambridge University
2720
http://sms.cam.ac.uk/media/2140293
Filament Based Lamellipodium Model (FBLM) modeling and numerical simulations
Sfakianakis, N (Johannes GutenbergUniversität Mainz)
Tuesday 8th December 2015  14:15 to 15:00
The cytoskeleton is a cellular skeleton inside the cytoplasm of living cells. The front of the cytoskeleton, also known as lamellipodium and is the driving mechanism of cell motility and is comprised by long double helix polymers of actin protein termed actinfilaments. The actinfilaments polymerize/depolymerize and exhibit a series of physical properties like elasticity, friction with the substrate, crosslink binding, repulsion, myosindrive contractility, nucleation, fragmentation, capping and more.
In this talk we address the FBLM that describes the above (microspcopic) dynamics of the actinfilaments and results to the (macroscopic) movement of the cell. We introduce the Finite Element Method (FEM) used to simulate this system and present numerical experiments exhibiting the motility of the cells in a series biological scenaria (including chemotactic and haptotactic influence) and compare our results with onvitro experiments.
Joint work(s) with Chr. Schmeiser, D. Oelz, A. Manhart, V. Small
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:28:28+00:00
2720
2140293
true
16x9
false

Finite element methods in geometric integration
ucs_sms_1633792_2103569
http://sms.cam.ac.uk/media/2103569
Finite element methods in geometric integration
Pryer, T (University of Reading)
Tuesday 20th October 2015  11:00 to 12:00
Wed, 04 Nov 2015 17:12:16 +0000
Isaac Newton Institute
Pryer, T
21cee7abe97d95c18c8c3312be221126
62ec6a517aeb7d483c1308feb03fe394
fed5c7fdf109565be01c35e271df232d
Pryer, T (University of Reading)
Tuesday 20th October 2015  11:00 to 12:00
Pryer, T (University of Reading)
Tuesday 20th October 2015  11:00 to 12:00
Cambridge University
3840
http://sms.cam.ac.uk/media/2103569
Finite element methods in geometric integration
Pryer, T (University of Reading)
Tuesday 20th October 2015  11:00 to 12:00
Geometric integration is the study of numerical schemes which inherit some property from the continuum limit they approximate. In this talk we examine the role of finite element temporal discretisations of some model ODE problems, moving onto how they can be applied in semi and fully discrete numerical schemes for PDEs. The specific model we illustrate in this talk is the NavierStokesKorteweg equation which is a diffuse interface phase field model
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151104T17:12:17+00:00
3840
2103569
true
16x9
false

Free Boundary Problems from a Model for ReceptorLigand Dynamics
ucs_sms_1633792_2140279
http://sms.cam.ac.uk/media/2140279
Free Boundary Problems from a Model for ReceptorLigand Dynamics
Venkataraman, C (University of St Andrews)
Tuesday 8th December 2015  10:00 to 11:00
Mon, 21 Dec 2015 10:24:31 +0000
Isaac Newton Institute
Venkataraman, C
f5ade04f7daebc587d172885ac6617a9
1a20f50e44f2e9cde83e48dfb0b37e32
a8bd61cbae99c3f912d156509b1cdab8
5547d4d0b7b38e840cb5908a81bbfc27
Venkataraman, C (University of St Andrews)
Tuesday 8th December 2015  10:00...
Venkataraman, C (University of St Andrews)
Tuesday 8th December 2015  10:00 to 11:00
Cambridge University
2934
http://sms.cam.ac.uk/media/2140279
Free Boundary Problems from a Model for ReceptorLigand Dynamics
Venkataraman, C (University of St Andrews)
Tuesday 8th December 2015  10:00 to 11:00
Coauthors: Charles Elliott (Warwick), Thomas Ranner (Leeds)
We consider a coupled bulksurface system of partial differential equations with nonlinear coupling that models receptorligand dynamics. The model arises as a simplification of a mathematical model for the reaction between cell surface resident receptors and ligands present in the ECM.
We prove the existence and uniqueness of a solution to the model and we also consider a number of biologically relevant asymptotic limits of the model. We prove convergence to the limiting problems, which take the form of free boundary problems posed on the cell surface. We also present numerical simulations in a realistic geometry.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:24:31+00:00
2934
2140279
true
16x9
false

Grand Challenge and Other Funding Opportunities at Cancer Research UK
ucs_sms_1633792_2140480
http://sms.cam.ac.uk/media/2140480
Grand Challenge and Other Funding Opportunities at Cancer Research UK
Meredith, J (Cancer Research UK)
Wednesday 9th December 2015  15:20 to 15:50
Mon, 21 Dec 2015 11:02:17 +0000
Isaac Newton Institute
Meredith, J
9362bc81508389e74fad6ff35b531b1e
87c88c200f896c79b35a7411986de2d6
2bf22510d63dc9646bd3bf2d381ddde4
9c351d644778cbbdbf4d47a10aba6566
Meredith, J (Cancer Research UK)
Wednesday 9th December 2015  15:20 to 15:50
Meredith, J (Cancer Research UK)
Wednesday 9th December 2015  15:20 to 15:50
Cambridge University
1748
http://sms.cam.ac.uk/media/2140480
Grand Challenge and Other Funding Opportunities at Cancer Research UK
Meredith, J (Cancer Research UK)
Wednesday 9th December 2015  15:20 to 15:50
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:02:17+00:00
1748
2140480
true
16x9
false

How a Volvox embryo turns itself inside out
ucs_sms_1633792_2030492
http://sms.cam.ac.uk/media/2030492
How a Volvox embryo turns itself inside out
Goldstein, R (University of Cambridge)
Wednesday 15th July 2015, 10:45 to 12:00
Fri, 17 Jul 2015 18:38:50 +0100
Isaac Newton Institute
Goldstein, R
52ad8082d9182568094d586ada8a7c0d
a0aa85e0cf007d2bd10700df8d43512d
8c87d7ebd3e0c95c06a445514a7b82e9
fa48684ba7027eb5c44417fbd90429c2
Goldstein, R (University of Cambridge)
Wednesday 15th July 2015, 10:45 to...
Goldstein, R (University of Cambridge)
Wednesday 15th July 2015, 10:45 to 12:00
Cambridge University
5460
http://sms.cam.ac.uk/media/2030492
How a Volvox embryo turns itself inside out
Goldstein, R (University of Cambridge)
Wednesday 15th July 2015, 10:45 to 12:00
During the growth of daughter colonies of the multicellular alga Volvox the spherical embryos must turn themselves inside out to complete their development. This process of 'inversion' has many features in common with gastrulation, the process by which an initially convex spherical shell of animal cells develops an invagination, leading to the formation of a gastric system. In both cases it is understood that cell shape changes play a major role in guiding the process, but quantification of the dynamics, and formulation of a mathematical description of the process, have been lacking. In this talk I will describe advances my group has made recently on both fronts. Using the technique of SPIM (selective plane illumination microscopy) we have obtained the first realtime threedimensional timelapse movies of inversion in Volvox, using several species displaying distinct morphological events. The beginnings of an elastic theory of these processes will also be described.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:38:50+01:00
5460
2030492
true
16x9
false

How cell forces shape tissue dynamics: from experiments to models
ucs_sms_1633792_2219866
http://sms.cam.ac.uk/media/2219866
How cell forces shape tissue dynamics: from experiments to models
Schwarz, U S (RuprechtKarlsUniversität Heidelberg)
Friday 18th Sep 2015, 09:00  10:00
Tue, 12 Apr 2016 09:18:21 +0100
Isaac Newton Institute
Schwarz, U S
f1bc29bb06fc811ab71ee3c5235976bf
f88a81eaaf89ffbeba7abe716bb7cfe0
707fb23c8a9fba110ae0e4cc6cad88f6
695315c8a475cbfb7e3a51d5a39d24a6
Schwarz, U S (RuprechtKarlsUniversität Heidelberg)
Friday 18th Sep 2015,...
Schwarz, U S (RuprechtKarlsUniversität Heidelberg)
Friday 18th Sep 2015, 09:00  10:00
Cambridge University
4200
http://sms.cam.ac.uk/media/2219866
How cell forces shape tissue dynamics: from experiments to models
Schwarz, U S (RuprechtKarlsUniversität Heidelberg)
Friday 18th Sep 2015, 09:00  10:00
Coauthors: Carina Dunlop (University of Surrey), Christoph Koke (Heidelberg University), Takuma Kanesaki (Göttingen University), Jörg Grosshans (Göttingen University), Philipp Albert (Heidelberg University)
In this contribution we will use two different biological model systems to illustrate how experimental observations can be integrated in appropriate mathematical models that describe tissue dynamics as they emerge from the cytoskeletal forces generated by single cells. Our first example is the syncytium of Drosophila melanogaster, which is shared by up to 6.000 nuclei that before cellularization divide four times in a thin layer without forming cell walls. Using confocal microscopy, quantitative image processing, tracking of single nuclei and evaluation of an appropriate measure for order, we have shown that each division constitutes a significant disordering of the nuclear array that is restored within a few minutes by the syncytial cytoskeleton. Interestingly, between divisions actin caps act as spacers while microtubules impart some attractive interactions. We have implemented these cytoskeletal elements in an individualbased computer simulation that predict under which conditions a stable ordering process will occur. Our second example is the dynamics of cell monolayers on flat substrates, an important model for wound healing. We investigate this situation with a cellular Potts model extending our earlier work on single cells. While cellcell adhesion together with actomyosin contractility ensures the cohesion of this system, cellmatrix adhesion together with actinbased protrusion makes the cell monolayer highly dynamic. We have implemented observationbased rules for cell mechanics, adhesion, divison and movement in a computationally very efficient simulation framework. Our model describes a large range of experimental data, including the dynamics and shapes of cell monolayers on micropatterned adhesive substrates.
Related Links •http://www.thphys.uniheidelberg.de/~biophys/  Homepage of presenter
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160412T09:18:21+01:00
4200
2219866
true
16x9
false

How cells form cups
ucs_sms_1633792_2078110
http://sms.cam.ac.uk/media/2078110
How cells form cups
Kay, R (MRC Laboratory of Molecular Biology)
Tuesday 15th September 2015  10:00 to 11:00
Tue, 29 Sep 2015 11:51:19 +0100
Isaac Newton Institute
Kay, R
012015e2a441006234ef2e36628ecd65
54dd7922c1b175c6449d9e8e13f7e578
a23f22b62e68e776fb9f2502d383504f
a6761ade7f09a95ecc84c57abcd67968
Kay, R (MRC Laboratory of Molecular Biology)
Tuesday 15th September 2015 ...
Kay, R (MRC Laboratory of Molecular Biology)
Tuesday 15th September 2015  10:00 to 11:00
Cambridge University
3720
http://sms.cam.ac.uk/media/2078110
How cells form cups
Kay, R (MRC Laboratory of Molecular Biology)
Tuesday 15th September 2015  10:00 to 11:00
Many cells can take in relatively large solid objects or droplets of medium by forming cupshaped structures from their plasma membrane. These projections extend, close, and after membrane fusion produce an intracellular vesicle in which the contents can be digested and useful molecules extracted. Cups are extended from the plasma membrane by a ring of actin polymerization which can be several microns in diameter. In the uptake of solid particles – phagocytosis – the particle itself is thought to trigger uptake and guide formation of the cup that engulfs it. However, in the case of fluid uptake, no such template is available, and the questions arises of how can a cell organize actin polymerisation into a ring? Dictyostelium amoebae are adept at both phagocytosis and macropinocytosis, and I will describe how our recent work leads to a hypothesis of actin ring formation.
Related Links
http://www2.mrclmb.cam.ac.uk/groups/rrk/  Personal web site
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T11:51:19+01:00
3720
2078110
true
16x9
false

Hydrodynamic diffuse interface models for Helfrich and mean curvature flow and their application to cells in fluid environment
ucs_sms_1633792_2103583
http://sms.cam.ac.uk/media/2103583
Hydrodynamic diffuse interface models for Helfrich and mean curvature flow and their application to cells in fluid environment
Marth, W (Technische Universität Dresden)
Tuesday 27th October 2015  11:00 to 12:30
Wed, 04 Nov 2015 17:19:48 +0000
Isaac Newton Institute
Marth, W
e565d0053a838f9eb2f305d783c88b19
d561200827d3433646c45d173748b6c4
8cd4f7c5d55eaeb6456077b35762a6f0
Marth, W (Technische Universität Dresden)
Tuesday 27th October 2015  11:00 to...
Marth, W (Technische Universität Dresden)
Tuesday 27th October 2015  11:00 to 12:30
Cambridge University
4260
http://sms.cam.ac.uk/media/2103583
Hydrodynamic diffuse interface models for Helfrich and mean curvature flow and their application to cells in fluid environment
Marth, W (Technische Universität Dresden)
Tuesday 27th October 2015  11:00 to 12:30
Helfrich and mean curvature flow are widely used to describe the physics of cell membranes. In this talk I will show how such hydrodynamic models can be derived and coupled to additional physical effects such as reactiondiffusion kinetics, liquid crystals or the interaction of multiple cells. We will apply these models to numerically simulate cell motility and white blood cell margination.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151104T17:19:48+00:00
4260
2103583
true
16x9
false

Image driven modelling of cell motility
ucs_sms_1633792_2078378
http://sms.cam.ac.uk/media/2078378
Image driven modelling of cell motility
Venkataraman, C (University of Sussex)
Friday 18th September 2015  13:30 to 14:15
Tue, 29 Sep 2015 17:05:10 +0100
Isaac Newton Institute
Venkataraman, C
1109f04755ea8ce317062952024eaedb
3ce304cfa8f4b3ad18b4f4465993b0db
f32ee299b2633b6e69b2a6cad4016893
Venkataraman, C (University of Sussex)
Friday 18th September 2015  13:30 to...
Venkataraman, C (University of Sussex)
Friday 18th September 2015  13:30 to 14:15
Cambridge University
2304
http://sms.cam.ac.uk/media/2078378
Image driven modelling of cell motility
Venkataraman, C (University of Sussex)
Friday 18th September 2015  13:30 to 14:15
Modern molecular biology, microscopy and imaging techniques allow the acquisition of large amounts of high resolution images of migrating cells. In this talk, I will present some initial steps towards using such imaging data in the development of mathematical models of cell migration. Time permitting, we will focus on two examples, a model for monopolar and bipolar growth of the fission yeast S. Pombe and a phase field approach to whole cell tracking. The first involves the use of qualitative features observed in the data to refine the modelling while the second illustrates some first steps towards model quantification using imaging data.
Related Links
http://arxiv.org/abs/1504.05399  Preprint on a phase field approach to cell tracking
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T17:05:11+01:00
2304
2078378
true
16x9
false

Intravital microscopy of the immune system
ucs_sms_1633792_2033225
http://sms.cam.ac.uk/media/2033225
Intravital microscopy of the immune system
Vrisekoop, N
Monday 20th July 2015, 15:15 to 16:30
Wed, 22 Jul 2015 16:57:16 +0100
Isaac Newton Institute
Vrisekoop, N
882eba8e064cf17d278733afc8585e9f
dada17779b4d6fe93a1b5026f93f2097
269060bbb8d312f0661c39001f518cd9
324bf2a6f45df8720ab920eafecb5176
Vrisekoop, N
Monday 20th July 2015, 15:15 to 16:30
Vrisekoop, N
Monday 20th July 2015, 15:15 to 16:30
Cambridge University
4560
http://sms.cam.ac.uk/media/2033225
Intravital microscopy of the immune system
Vrisekoop, N
Monday 20th July 2015, 15:15 to 16:30
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150722T16:57:16+01:00
4560
2033225
true
16x9
false

Localized pulse solutions in FitzHughNagumo equations
ucs_sms_1633792_2083025
http://sms.cam.ac.uk/media/2083025
Localized pulse solutions in FitzHughNagumo equations
Chen, CN (National Tsing Hua University)
Tuesday 8th September 2015  11:00 to 12:30
Tue, 06 Oct 2015 14:39:22 +0100
Isaac Newton Institute
Chen, CN
ae6059692683b1ee1640cba3912c5836
35df10398c29b9c917ccf2ac3e6593c7
ce09cc4c052148c788b5663184ee20b8
b5b8f98b85a7ff919f8810ddc95333f0
Chen, CN (National Tsing Hua University)
Tuesday 8th September 2015  11:00...
Chen, CN (National Tsing Hua University)
Tuesday 8th September 2015  11:00 to 12:30
Cambridge University
3900
http://sms.cam.ac.uk/media/2083025
Localized pulse solutions in FitzHughNagumo equations
Chen, CN (National Tsing Hua University)
Tuesday 8th September 2015  11:00 to 12:30
Particlelike structures are commonly observed in physical, chemical and biological systems. Depending on the system parameters and initial conditions, localized dissipative structures may stay at rest or propagate with a dynamically stabilized velocity. In this talk we aim at some variational methods for studying pulse solutions to FitzHughNagumo equations.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151006T14:39:22+01:00
3900
2083025
true
16x9
false

Lonely in a group: Single and collective cell behaviour in 3D environments
ucs_sms_1633792_2060637
http://sms.cam.ac.uk/media/2060637
Lonely in a group: Single and collective cell behaviour in 3D environments
Zaman, M (Boston University)
Thursday 27 August 2015, 11:0012:00
Mon, 28 Sep 2015 14:08:25 +0100
Isaac Newton Institute
Zaman, M
c715732ce096930482a4c2e5251ad397
2bd4e03c75edfdfc029b92bb9f0debe8
ca336532aa3513438e1f3a98d4287e97
7683cdf40a5d40495beb445f848eae3d
Zaman, M (Boston University)
Thursday 27 August 2015, 11:0012:00
Zaman, M (Boston University)
Thursday 27 August 2015, 11:0012:00
Cambridge University
3168
http://sms.cam.ac.uk/media/2060637
Lonely in a group: Single and collective cell behaviour in 3D environments
Zaman, M (Boston University)
Thursday 27 August 2015, 11:0012:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150928T14:08:26+01:00
3168
2060637
true
16x9
false

Making Holes: Identifying How Metastatic Cancer Cells Apply Force to Invade Their Microenvironment
ucs_sms_1633792_2140215
http://sms.cam.ac.uk/media/2140215
Making Holes: Identifying How Metastatic Cancer Cells Apply Force to Invade Their Microenvironment
Weihs, D (Technion  Israel Institute of Technology)
Monday 7th December 2015  11:30 to 12:30
Mon, 21 Dec 2015 09:46:38 +0000
Isaac Newton Institute
Weihs, D
7c7d86c8077d6dbeaab5f70be8d8f809
3ca336822d1acac2bb352521153bb9bf
f565b6a4ef7f5987acf8cebb13fb7579
09f82f00d427cf1896551f06d57ce3e7
Weihs, D (Technion  Israel Institute of Technology)
Monday 7th December 2015...
Weihs, D (Technion  Israel Institute of Technology)
Monday 7th December 2015  11:30 to 12:30
Cambridge University
3528
http://sms.cam.ac.uk/media/2140215
Making Holes: Identifying How Metastatic Cancer Cells Apply Force to Invade Their Microenvironment
Weihs, D (Technion  Israel Institute of Technology)
Monday 7th December 2015  11:30 to 12:30
The process of invasion is of special importance in cancer metastasis, the main cause of death in cancer patients. Cells typically penetrate a matrix by degrading it or by squeezing through pores. However, cell mechanics and forces applied by cells especially during the initial stages of metastatic penetration, as metastatic cells indent a substrate, are still unknown. We measure the forces that cells apply to an impenetrable, synthetic 2dimensional gelmatrix, effectively limiting cells to rely only on mechanicalinteractions; gels are nondegradable polyacrylamide with submicron pores. We show that single metastatic breastcancer cells will apply force to an impenetrable gel, and indent it in attempted invasion, when the gel is in the appropriate stiffness range; benign cells do not indent the gels. The metastatic cells require gelsubstrates to be soft enough to indent, yet stiff enough to grip and generate force on. Cells develop grip handles and pull the underlying gel s inwards and upwards bringing the nucleus into the indentation concavity. We reveal a special coordinated role for the nucleus and the cytoskeleton when a single cell attempts to invade the impenetrable barrier. The actin, nucleus, and microtubules reorganize in sequence, with the actin at the leading edge of the cell. Cells repeatedly attempt penetration over several hours and then relocate, indicating an advanced mechanotransduction feedback loop. We use finite element analysis to identify force application patterns to maximize indentations, by varying cell size, shape and the locations and magnitudes of the mechanical loads applied by cells. We demonstrate that cells must combine lateral forces and significant normal forces to achieve the large, experimentally observed gelindentations. The systems and analysis approaches shown here reveal cell adaptability and force application mechanisms.
Related Links
http://www.weihs.net.technion.ac.il/  Laboratory website
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T09:46:38+00:00
3528
2140215
true
16x9
false

Making VirtualTissue Modeling an Integral Tool in Biology
ucs_sms_1633792_2036212
http://sms.cam.ac.uk/media/2036212
Making VirtualTissue Modeling an Integral Tool in Biology
Glazier, J (Indiana University)
Wednesday 22nd July 2015, 10:45 to 12:00
Mon, 27 Jul 2015 15:16:31 +0100
Isaac Newton Institute
Glazier, J
e978346eeaf6c2d5f2ae128a6d37446d
ae16fc6e017b6f1298dad96e31279f88
fc593d7aa65c6af767a1487c4b339dbc
2ec447de647442b78e7d8794bc5658b5
Glazier, J (Indiana University)
Wednesday 22nd July 2015, 10:45 to 12:00
Glazier, J (Indiana University)
Wednesday 22nd July 2015, 10:45 to 12:00
Cambridge University
5700
http://sms.cam.ac.uk/media/2036212
Making VirtualTissue Modeling an Integral Tool in Biology
Glazier, J (Indiana University)
Wednesday 22nd July 2015, 10:45 to 12:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150727T15:16:31+01:00
5700
2036212
true
16x9
false

Mathematical modelling of angiogenesis in wounds, tumours and retinae: The good, the bad and the beautiful
ucs_sms_1633792_2140208
http://sms.cam.ac.uk/media/2140208
Mathematical modelling of angiogenesis in wounds, tumours and retinae: The good, the bad and the beautiful
Chaplain, M (University of St Andrews)
Monday 7th December 2015  10:00 to 11:00
Mon, 21 Dec 2015 09:51:05 +0000
Isaac Newton Institute
Chaplain, M
0862d315637151d8f67ae7ba6a7affd4
b6c2a3c17cc36adaaa11ae494effd685
5bb8c9223f271c45fca66a4fee27ff93
79000f486785a15a50d46e8ef44ec04e
Chaplain, M (University of St Andrews)
Monday 7th December 2015  10:00 to...
Chaplain, M (University of St Andrews)
Monday 7th December 2015  10:00 to 11:00
Cambridge University
4140
http://sms.cam.ac.uk/media/2140208
Mathematical modelling of angiogenesis in wounds, tumours and retinae: The good, the bad and the beautiful
Chaplain, M (University of St Andrews)
Monday 7th December 2015  10:00 to 11:00
Angiogenesis is the growth of a new network of blood vessels from a preexisting vasculature. As a process, angiogenesis is a wellorchestrated sequence of events involving endothelial cell migration and proliferation; degradation of tissue; new capillary vessel (sprout) formation; loop formation (anastomosis) and, crucially, blood flow through the network. Once there is blood flow associated with the nascent network, the subsequent growth of the network evolves both temporally and spatially in response to the combined effects of angiogenic factors, migratory cues via the extracellular matrix and perfusionrelated haemodynamic forces in a manner that may be described as both adaptive and dynamic. Angiogenesis is a vital component of both normal and pathological processes such as wound healing, solid tumour growth and retinal development.
In this talk we will present a basic mathematical model for the development of a vascular network which simultaneously couples vessel growth with blood flow through the vessels  a dynamic adaptive vasculature model. We will then apply the model to three different biological scenarios: (i) tumourinduced angiogenesis; (ii) wound healing and (iii) the developing retina. The computational simulation results will be compared with experimental data and the predictions of the model discussed with regard to scheduling of the delivery of chemotherapy drugs to solid tumours.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T09:51:05+00:00
4140
2140208
true
16x9
false

Mathematical modelling of cancer invasion: The role of cell adhesion variability
ucs_sms_1633792_2140574
http://sms.cam.ac.uk/media/2140574
Mathematical modelling of cancer invasion: The role of cell adhesion variability
Domschke, P (Technische Universität Darmstadt)
Thursday 10th December 2015  15:30 to 16:15
Mon, 21 Dec 2015 11:10:39 +0000
Isaac Newton Institute
Domschke, P
0da0d81a2621ea5c101e5615ce682c89
79e77ef6302c04f4225268c23b79c81b
c474c5af8283c6c656d60846cf3e09a1
23f8aa83ca578779ad9ef5b1e6cbf779
Domschke, P (Technische Universität Darmstadt)
Thursday 10th December 2015 ...
Domschke, P (Technische Universität Darmstadt)
Thursday 10th December 2015  15:30 to 16:15
Cambridge University
2037
http://sms.cam.ac.uk/media/2140574
Mathematical modelling of cancer invasion: The role of cell adhesion variability
Domschke, P (Technische Universität Darmstadt)
Thursday 10th December 2015  15:30 to 16:15
Coauthors: Dumitru Trucu (University of Dundee), Alf Gerisch (TU Darmstadt), Mark Chaplain (University of St Andrews)
Cancer invasion is a complex process occurring across several spatial and temporal scales, perhaps the three most important being the intracellular, cellular and tissue scales. Key biological processes occurring during invasion are the secretion of matrix degrading enzymes, cell proliferation, the loss of cellcell adhesion on one hand and enhanced cellmatrix adhesion on the other hand, as well as active migration. The ability of cancer cells to alter or degrade the surrounding tissue enables the cancer cells to locally invade the neighbouring region. The movement of cancer cells occurs through chemotaxis as well as haptotaxis and is supported by the binding and unbinding of molecules on the cell surface to other cells and/or the extracellular matrix (ECM). The number and strength of these binding proteins define the magnitude of cellcell and cellmatrix adhesion and are modified by the cell’s microenvironment. Hence, the movement of the cells is not only determined l ocally but depends on the neighbourhood of the cell.
We explore the spatiotemporal dynamics of a mathematical model of cancer invasion, where cellcell and cellmatrix adhesion are accounted for through nonlocal interaction terms. A nonlocal model of cancer invasion for a single cancer cell population is extended to a structuredpopulation model with n cancer cell subpopulations, which may mutate into each other. The change of adhesion properties during the growth of the cancer is investigated through timedependent adhesion parameters within the cancer cell subpopulations as well as those between the cancer cells and the components of the extracellular matrix. We focus on one and two cancer cell subpopulation models in two spatial dimensions, which show heterogeneous dynamics in our computational simulation results.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160229T10:48:57+00:00
2037
2140574
false
16x9
false

Mechanical signals and morphogenesis in plants
ucs_sms_1633792_2078207
http://sms.cam.ac.uk/media/2078207
Mechanical signals and morphogenesis in plants
Bozorg, B (Lund University)
Wednesday 16th September 2015  16:15 to 17:00
Tue, 29 Sep 2015 15:02:57 +0100
Isaac Newton Institute
Bozorg, B
23b74dd5374e0f5ec66d6ad8db542191
a431a30f85d63d06ce7e1ad38fe9f07f
a0c1d09223f5c347e186cf5e3cab096e
002d0f1e72b6e43972bf4484bf6989c0
Bozorg, B (Lund University)
Wednesday 16th September 2015  16:15 to 17:00
Bozorg, B (Lund University)
Wednesday 16th September 2015  16:15 to 17:00
Cambridge University
3061
http://sms.cam.ac.uk/media/2078207
Mechanical signals and morphogenesis in plants
Bozorg, B (Lund University)
Wednesday 16th September 2015  16:15 to 17:00
Plants undergo large deformations during organ initiation and growth. Recent evidence is revealing the role of mechanical cues in these morphogenic events. Here we summarise our efforts to include properties such as varying elasticity, plasticity and mechanical anisotropy in time and space for modelling the plant tissue. Due to the key role of plant epidermis in morphogenesis, the plant tissue can be modelled as a pressure vessel. We modified the well known SaintVenant's strain energy model to represent anisotropic material. In our model the tuneable material anisotropy resembles fiber deposition in primary plant walls. In the meristem periphery circumferential cellulose fiber organisation is the main controller of longitudinal growth. In our model this can be achieved by applying a feedback from maximal stress direction to the fiber orientation. By considering the degree of material anisotropy and anisotropy direction as additional variables in a linear material model u nder plane stress condition, we could show that stress feedback model is in fact an energy minimization process. Though this finding is not sufficient to describe the underlying mechanism of potential stress feedback, it could be considered as an evolutionary motivation. We employed strain signal for regulating the differential plastic deformation. We showed that the behaviour of such model is mesh independent and in case of being used together with stress feedback model for anisotropic tissue can result in overall deformations favourable for development of plantlike shapes. Ignoring the internal structure in tissue pressure models is not realistic in various cases. Some patterning processes such as vein formation in meristem need to be investigated throughout the three dimensional structure of the tissue. We have also extended our model to study the capability of mechanical signals regulating the cell polarity which are crucial to Auxin patterning processes including the internal tissue structure.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T15:02:58+01:00
3061
2078207
true
16x9
false

Mechanisms shaping endoplasmic reticulum
ucs_sms_1633792_2032539
http://sms.cam.ac.uk/media/2032539
Mechanisms shaping endoplasmic reticulum
Kozlov, M (Tel Aviv University)
Friday 17th July 2015, 15:15 to 16:30
Tue, 21 Jul 2015 13:42:48 +0100
Isaac Newton Institute
Kozlov, M
73d828c3d89e2571617f2ba2f951c06f
6edbb7cb69b74dad69ccf58f38ae6d90
d79ccc9a9d4da75c85f0b48ca9a8da1f
c4c96a84ac2a050e62bbd60874addb80
Kozlov, M (Tel Aviv University)
Friday 17th July 2015, 15:15 to 16:30
Kozlov, M (Tel Aviv University)
Friday 17th July 2015, 15:15 to 16:30
Cambridge University
5280
http://sms.cam.ac.uk/media/2032539
Mechanisms shaping endoplasmic reticulum
Kozlov, M (Tel Aviv University)
Friday 17th July 2015, 15:15 to 16:30
Membranes of intracellular organelles and transport intermediates acquire shapes with large curvatures and complex morphologies, and undergo persistent remodeling by fission and fusion. We suggest a unifying mechanistic framework for understanding how specialized peripheral membrane proteins control the intracellular membrane curvature and dynamics, and address the effects of several specific proteins. Our consideration is based on two major mechanisms by which proteins shape membranes: shallow insertion into the membrane matrix of amphipathic or hydrophobic protein domains, and membrane attachment to the strongly curved and rigid faces of hydrophilic protein scaffolds. We considering the scaffolding mechanism, by model computationally the shaping of endoplasmic reticulum (ER ) membranes by oligomers of reticulon and DP1/Yop1 family proteins. We demonstrate that membrane molding by these proteins into nearly halfcylindrical shapes underlies generation of the whole plethora of complex morphologies observed to date in ER of different cells, which include ER tubules, sheets, intertubular threeway junctions, intersheet helicoidal connections and sheet fenestrations.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150721T13:42:48+01:00
5280
2032539
true
16x9
false

Mechanobiology of cells
ucs_sms_1633792_2030527
http://sms.cam.ac.uk/media/2030527
Mechanobiology of cells
Merkel, R (Forschungszentrum Jülich)
Thursday 16th July 2015, 13:30 to 14:45
Fri, 17 Jul 2015 18:40:42 +0100
Isaac Newton Institute
Merkel, R
3b5f9b5259b76744e5b72005225ce85b
da0d83ac8bb990b7b819295d78617a0d
823a7aece945ee77a1ed1cf2d4b26130
54ab54f7a5bc40da7d8f7e7d7474cb6b
Merkel, R (Forschungszentrum Jülich)
Thursday 16th July 2015, 13:30 to 14:45...
Merkel, R (Forschungszentrum Jülich)
Thursday 16th July 2015, 13:30 to 14:45
Cambridge University
4740
http://sms.cam.ac.uk/media/2030527
Mechanobiology of cells
Merkel, R (Forschungszentrum Jülich)
Thursday 16th July 2015, 13:30 to 14:45
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:40:42+01:00
4740
2030527
true
16x9
false

Membrane dynamics
ucs_sms_1633792_2032532
http://sms.cam.ac.uk/media/2032532
Membrane dynamics
Smith, A (FriedrichAlexanderUniversität ErlangenNürnberg)
Friday 17th July 2015, 13:30 to 14:45
Tue, 21 Jul 2015 13:30:50 +0100
Isaac Newton Institute
Smith, A
a3f0c38af57f127a2757c24004edf482
f1ecf3c65f4f24a52502320a4dcd62fa
46610a9c2b4ecd006935af6a3ad61adb
19178c71dc4cce8d4dbf2f75d035fb0f
Smith, A (FriedrichAlexanderUniversität ErlangenNürnberg)
Friday 17th July...
Smith, A (FriedrichAlexanderUniversität ErlangenNürnberg)
Friday 17th July 2015, 13:30 to 14:45
Cambridge University
4740
http://sms.cam.ac.uk/media/2032532
Membrane dynamics
Smith, A (FriedrichAlexanderUniversität ErlangenNürnberg)
Friday 17th July 2015, 13:30 to 14:45
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150721T13:30:50+01:00
4740
2032532
true
16x9
false

Membrane remodeling and cellular morphogenesis during plant tissue colonization
ucs_sms_1633792_2140315
http://sms.cam.ac.uk/media/2140315
Membrane remodeling and cellular morphogenesis during plant tissue colonization
Dagdas, Y (University of East Anglia)
Wednesday 9th December 2015  10:00 to 11:00
Mon, 21 Dec 2015 10:37:26 +0000
Isaac Newton Institute
Dagdas, Y
dd95eb5a1f791b9495720317873c9bf2
62ec98d71af1e1badc95ce59d498451c
88a14e40f43277d857b66ae105fb373f
af91f6216869c6fbdc60f1fe6fd8b155
Dagdas, Y (University of East Anglia)
Wednesday 9th December 2015  10:00 to...
Dagdas, Y (University of East Anglia)
Wednesday 9th December 2015  10:00 to 11:00
Cambridge University
2795
http://sms.cam.ac.uk/media/2140315
Membrane remodeling and cellular morphogenesis during plant tissue colonization
Dagdas, Y (University of East Anglia)
Wednesday 9th December 2015  10:00 to 11:00
One of the biggest challenges of 21st century is feeding the growing human population. Plant pathogens cause devastating yield losses in staple crops and pose a serious threat to global food security. According to recent reports, plant pathogens cause crop losses that if alleviated would feed at least 700 million people. To prevent crop loses due to pathogens, we have to understand plantmicrobe interactions at molecular and systems level. To facilitate plant colonization these deadly microbes evolved unique infection strategies. They form specialized infection cells that involve tightly controlled spatiotemporal repolarization events. Additionally, pathogens also induce extensive membrane remodeling within plant tissues. They initiate plant infection via invagination of plant plasma membrane and reorient cellular resources to these infection cells. They can occupy up to 80% of plant cell volume without inducing any immune response. We have limited knowledge on the molecular details of infection cell morphogenesis and cellular reprogramming during plant infection. I will present our recent results on rice blast and Irish potato famine pathogen and propose research questions that can be answered using mathematical modeling.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:37:26+00:00
2795
2140315
true
16x9
false

Migration of epithelial cells
ucs_sms_1633792_2029306
http://sms.cam.ac.uk/media/2029306
Migration of epithelial cells
Hoffmann, B (Forschungszentrum Jülich)
Monday 13th July 2015, 14:30  15:30
Wed, 15 Jul 2015 18:35:59 +0100
Isaac Newton Institute
Hoffmann, B
3300d420e824b28513174e3ae1ac7620
d27649b746a886106a55000582676a11
b3ffd40207c3e48847bcbf35145bdc65
ea8d81713d2aefbd0c617a2159b213cf
Hoffmann, B (Forschungszentrum Jülich)
Monday 13th July 2015, 14:30  15:30
Hoffmann, B (Forschungszentrum Jülich)
Monday 13th July 2015, 14:30  15:30
Cambridge University
4020
http://sms.cam.ac.uk/media/2029306
Migration of epithelial cells
Hoffmann, B (Forschungszentrum Jülich)
Monday 13th July 2015, 14:30  15:30
Epithelial cells play a vital role for mechanical integrity at the tissue level by forming a stable cell layer that is connected to the extracellular environment via various cellcell as well as cellmatrix junctions. However, upon signal induction cells can undergo dramatic morphological changes to switch from a sessile to a highly motile phenotype. Characterized by intense cell polarization a concerted interplay at the level of cytoskeletal dynamics, cell adhesion, force generation, and protein affinity regulation takes place leading to an overall uniform migratory behavior. Although hundreds of molecules and regulatory events are involved, four main steps, namely I) actin polymerization at the cell front, II) adhesion formation, III) cell contraction and IV) deadhesion at the rear end of the cell characterize the complete motility cycle of epithelial cells making epithelial cells to an ideal model system in order to study basic cell motility events.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:35:59+01:00
4020
2029306
true
16x9
false

Minimising a relaxed Willmore functional for graphs subject to Dirichlet boundary conditions
ucs_sms_1633792_2083033
http://sms.cam.ac.uk/media/2083033
Minimising a relaxed Willmore functional for graphs subject to Dirichlet boundary conditions
Deckelnick, K
Thursday 10th September 2015  11:00 to 12:30
Tue, 06 Oct 2015 14:40:56 +0100
Isaac Newton Institute
Deckelnick, K
e2e08b83ee2eee17a3ce594e9b995a3a
693c8f6b4f9ae7505c94f192e8309bcf
b2dfa8a17f10b80ec165db321ca984ee
a4a11d1ce91cd97d9319c06189377795
Deckelnick, K
Thursday 10th September 2015  11:00 to 12:30
Deckelnick, K
Thursday 10th September 2015  11:00 to 12:30
Cambridge University
3720
http://sms.cam.ac.uk/media/2083033
Minimising a relaxed Willmore functional for graphs subject to Dirichlet boundary conditions
Deckelnick, K
Thursday 10th September 2015  11:00 to 12:30
For a bounded smooth domain Ω in the plane we consider the minimisation of the Willmore functional for graphs subject to Dirichlet boundary conditions. In a first step we show that sequences of functions with bounded Willmore energy satisfy uniform area and diameter bounds yielding compactness in L1(Ω). We therefore introduce the L1lower semicontinuous relaxation and prove that it coincides with the Willmore functional on the subset of H2(Ω) satisfying the given Dirichlet boundary conditions. Furthermore, we derive properties of functions having finite relaxed Willmore energy with special emphasis on the attainment of the boundary conditions. Finally we show that the relaxed Willmore functional has a minimum in L∞(Ω)∩BV(Ω). This is joint work with HansChristoph Grunau (Magdeburg) and Matthias Röger (Dortmund).
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151006T14:40:56+01:00
3720
2083033
true
16x9
false

Modelling 3D cell motility in mechanochemobiology: from microfluidics to numerical simulation
ucs_sms_1633792_2078150
http://sms.cam.ac.uk/media/2078150
Modelling 3D cell motility in mechanochemobiology: from microfluidics to numerical simulation
García Aznar, J M (Universidad de Zaragoza)
Tuesday 15th September 2015  14:15 to 15:00
Tue, 29 Sep 2015 11:07:19 +0100
Isaac Newton Institute
García Aznar, J M
25debd117abd29c3c3eda0a4eaa620dc
14d0ac8d0128d6378c30f9d57e9d3380
2fef5e56fa5422a32c0effa50a039d16
García Aznar, J M (Universidad de Zaragoza)
Tuesday 15th September 2015 ...
García Aznar, J M (Universidad de Zaragoza)
Tuesday 15th September 2015  14:15 to 15:00
Cambridge University
2392
http://sms.cam.ac.uk/media/2078150
Modelling 3D cell motility in mechanochemobiology: from microfluidics to numerical simulation
García Aznar, J M (Universidad de Zaragoza)
Tuesday 15th September 2015  14:15 to 15:00
Coauthors: MorenoArotzena O (Universidad de Zaragoza), Ribeiro F (IST Lisbon), Borau C (Universidad de Zaragoza)
Cell motility is essential for many morphogenetic and regenerative processes, also contributing to the development of numerous diseases, including cancer. For 2D, cell movement starts with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the extracellular matrix, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Although valuable knowledge has been accumulated through analysis of various 2D models, some of these insights are not directly applicable to migration in 3D. In any case, all these processes are regulated by environmental signals from the surrounding microenvironment that allow cells to guide and regulate their directional movement. Unraveling the intrinsic mechanisms that cells use to define their migration is crucial for advancing in the development of new technologies in regenerative medicine and treatment of cancer. Due to the complexity of all these mechanisms, the combination of invitro models (through microfluidicsbased experiments) and computational simulations provide deeper insight and quantitative predictions of the mechanochemical interplay between cells and extracellular matrix during migration With this objective in mind, we have developed microfluidicbased studies of individual 3D fibroblast movement in biomimetic microenvironments provided by the matrix and the biochemical factors that are moving in the medium. In particular, we have confined two physiologically relevant hydrogels (collagen and fibrin) in combination with two growth factors (PDGFBB and TGFβ1). Meanwhile, we are developing novel numerical approaches that combine discrete and continuous numerical approaches in order to simulate this 3D cell migration. So, in this work, I will show recent progress that we have made in the development of different integrative numerical strategies for advancing in the simulation of cell movement in 3D
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T11:07:19+01:00
2392
2078150
true
16x9
false

Modelling chemotactic motion of cells in biological tissues
ucs_sms_1633792_2078200
http://sms.cam.ac.uk/media/2078200
Modelling chemotactic motion of cells in biological tissues
Vasiev, B (University of Liverpool)
Wednesday 16th September 2015 n15:30 to 16:15
Tue, 29 Sep 2015 14:55:19 +0100
Isaac Newton Institute
Vasiev, B
223a3e3856536e7dd421c8e88f3b4e65
432a7c4ab17435eee8028c0789c7bc3f
4c94d7f6e291511c1e0e9a73d4272369
Vasiev, B (University of Liverpool)
Wednesday 16th September 2015 n15:30 to...
Vasiev, B (University of Liverpool)
Wednesday 16th September 2015 n15:30 to 16:15
Cambridge University
2961
http://sms.cam.ac.uk/media/2078200
Modelling chemotactic motion of cells in biological tissues
Vasiev, B (University of Liverpool)
Wednesday 16th September 2015 n15:30 to 16:15
Developmental processes in biology are underlined by proliferation, differentiation and migration of cells. The latter two are interlinked since cellular differentiation is governed by the dynamics of morphogens which, in turn, is affected by the movement of cells. Mutual effects of morphogenetic and cell movement patterns are enhanced when the movement is due to chemotactic response of cells to the morphogens. In this presentation I introduce mathematical models to analyse how this interplay results into formation of propagating wave solution in a concentration field of a morphogen and associated steady movement of cells in tissue. It is found that a single cell or a group of cells of certain cell type surrounded by cells of another type can push itself to move, provided that it produces a chemical which acts as a chemorepellent to its constituent cells. Also, the group of cells can be pulled to move if it is attracted by a morphogen produced by the surrounding cells in a ti ssue. Even when the group is formed by cells which are not chemotacticaly active, it can move when surrounding cells are attracted chemotactically by the morphogen produced outside the moving group or repelled by the morphogen produced inside the group. In all cases the motion is possible if the chemotactic response is stronger than a certain threshold defined by the kinetics of the morphogen. The model is also extended to consider proliferation and differentiation of cells forming the moving group.
Related Links
http://www.liv.ac.uk/mathematicalsciences/staff/bakhtiervasiev/
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T14:55:19+01:00
2961
2078200
true
16x9
false

Modelling intermediate filaments
ucs_sms_1633792_2078133
http://sms.cam.ac.uk/media/2078133
Modelling intermediate filaments
Portet, S (University of Manitoba)
Tuesday 15th September 2015  11:30 to 12:30
Tue, 29 Sep 2015 11:29:09 +0100
Isaac Newton Institute
Portet, S
7c67acb84c40620515d61611a15fc06c
fc90bb136b9ea3dce7406feab8601a46
d23330787dd968181c890aab74d00329
d12f3f8476a58a1bc6928f977f5dd7be
Portet, S (University of Manitoba)
Tuesday 15th September 2015  11:30 to 12:30
Portet, S (University of Manitoba)
Tuesday 15th September 2015  11:30 to 12:30
Cambridge University
3471
http://sms.cam.ac.uk/media/2078133
Modelling intermediate filaments
Portet, S (University of Manitoba)
Tuesday 15th September 2015  11:30 to 12:30
Intermediate filaments are one of the components of cytoskeletal networks. Intermediate filaments play a crucial role in the cell mechanics. Understanding their assembly dynamics, organization in networks and resulting mechanical properties is essential to elucidate their functions in cells. A combination of mathematical modelling and experimental data is used to investigate the organization of the intermediate filament networks. What contributes to their organization? What process or combination of processes does the organization emerge from? What process dominates?
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T11:29:10+01:00
3471
2078133
true
16x9
false

Modelling of crosslinked fiber networks and tissue selforganization
ucs_sms_1633792_2140534
http://sms.cam.ac.uk/media/2140534
Modelling of crosslinked fiber networks and tissue selforganization
Degond, P (Imperial College London)
Thursday 10th December 2015  11:30 to 12:30
Mon, 21 Dec 2015 11:27:25 +0000
Isaac Newton Institute
Degond, P
b30417cf6ba0d6333d491a22bfcc83bf
17bf9090909ad1f2b18a9f2c303c58f5
63f59c78fdc3ec61258bb869c940d984
dbb76f378d1055ee499ec59cecb4f63f
Degond, P (Imperial College London)
Thursday 10th December 2015  11:30 to...
Degond, P (Imperial College London)
Thursday 10th December 2015  11:30 to 12:30
Cambridge University
3780
http://sms.cam.ac.uk/media/2140534
Modelling of crosslinked fiber networks and tissue selforganization
Degond, P (Imperial College London)
Thursday 10th December 2015  11:30 to 12:30
In this talk, we will derive a continuum model for the dynamics of a network of crosslinked fibers. We will outline how this model can be applied to the modelling of tissue selforganization.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:27:26+00:00
3780
2140534
true
16x9
false

Modelling Residual Stresses Modelling Residual Stresses in Heart and Arteries
ucs_sms_1633792_2078283
http://sms.cam.ac.uk/media/2078283
Modelling Residual Stresses Modelling Residual Stresses in Heart and Arteries
Luo, X (University of Glasgow)
Thursday 17th September 2015  16:15 to 17:00
Tue, 29 Sep 2015 16:23:12 +0100
Isaac Newton Institute
Luo, X
339003b7b662f9cd850026eff4f56816
30dda58dab7b88ae5003e46759b2c97a
d067a46e87ec1578285783df936bbfa2
f1b0d2b97311aeafd1e885ea60947bb0
Luo, X (University of Glasgow)
Thursday 17th September 2015  16:15 to 17:00
Luo, X (University of Glasgow)
Thursday 17th September 2015  16:15 to 17:00
Cambridge University
3207
http://sms.cam.ac.uk/media/2078283
Modelling Residual Stresses Modelling Residual Stresses in Heart and Arteries
Luo, X (University of Glasgow)
Thursday 17th September 2015  16:15 to 17:00
This talk will start with an overview of the invariantbased continuum mechanics approach for anisotropic soft tissues that undergo large nonlinear deformation. I will then focus on the modelling of residual stress in such a setting. Residual stress is important in the mechanical behaviour of the living organs, and reflects the accumulated changes due to growth and remodelling over time. However, in many computational models, effects of residual stresses are overlooked. I will report how we consider the residual stress using the opening angle method with applications to left ventricle and aortic dissection. Results with and without the residual stress will be discussed. Finally, I will show that although it is commonly accepted that residual stress may be released in arteries from a single radial cut, this is not true in general. Indeed with two cuts or more, the maximum residual hoop stress could be as great as 35 times compared to that of the single cut. Further work is clearly required to investigate this and to link the continuum models to growth and modelling processes occurred at the cellular levels. Key words: residual stress, opening angle method, left ventricle model, aortic dissection.
Related Links
http://www.maths.gla.ac.uk/~xl/  personal website
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T16:23:12+01:00
3207
2078283
true
16x9
false

Models for growth development in cell motility and pattern formation
ucs_sms_1633792_2029285
http://sms.cam.ac.uk/media/2029285
Models for growth development in cell motility and pattern formation
Madzvamuse, A (University of Sussex)
Monday 13th July 2015, 09:45  10:30
Wed, 15 Jul 2015 18:01:42 +0100
Isaac Newton Institute
Madzvamuse, A
ee51c69163e5ed57a805226e9c03654e
0538386de849dc346e4218b357d8a087
0b30b6043e9314ece6688ac101a45811
c1daef24820b8209d16c5d0f4c2097ee
Madzvamuse, A (University of Sussex)
Monday 13th July 2015, 09:45  10:30
Madzvamuse, A (University of Sussex)
Monday 13th July 2015, 09:45  10:30
Cambridge University
2794
http://sms.cam.ac.uk/media/2029285
Models for growth development in cell motility and pattern formation
Madzvamuse, A (University of Sussex)
Monday 13th July 2015, 09:45  10:30
The aim of this lecture is stimulate discussions on the development of new theoretical and computational models coupling internal (bulk), surface and external (extracellular matrix) dynamics for cell motility and pattern formation. Underpinning this framework are numerous open problems associated with analysis of the models, development of efficient and robust numerical methods as well as fitting models (qualitatively and quantitatively) to experimental observations (data) through optimal control models.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T18:01:42+01:00
2794
2029285
true
16x9
false

Models in Wound Healing: Scar Tissue and Contraction
ucs_sms_1633792_2047014
http://sms.cam.ac.uk/media/2047014
Models in Wound Healing: Scar Tissue and Contraction
Dallon, J (Brigham Young University)
Thursday 13 August 2015, 11:0012:00
Fri, 14 Aug 2015 12:10:45 +0100
Isaac Newton Institute
Dallon, J
2b7f59579fba992e7ea8a5edbc1c575b
3627cf08ff5875d58f7be36b65d4289f
9cd0a5c5bf0d856b0ef957c8f33cbacc
d21caf9380ff40cc129d594944849d31
Dallon, J (Brigham Young University)
Thursday 13 August 2015, 11:0012:00
Dallon, J (Brigham Young University)
Thursday 13 August 2015, 11:0012:00
Cambridge University
3600
http://sms.cam.ac.uk/media/2047014
Models in Wound Healing: Scar Tissue and Contraction
Dallon, J (Brigham Young University)
Thursday 13 August 2015, 11:0012:00
This talk will explain results from models on scar tissue formation and fibroblast populated collagen lattice contraction. The first set of models focus on the biochemical remodeling of the wound environment. The extracellular matrix is treated as a continuum, the cells are modeled as discrete objects,and the interactions between the two are investigated to better understand scar tissue formation. In the second set of models, mechanical forces are the focus to better understand wound contraction. Both the cells and the collagen lattice are modeled as discrete structures in the fibroblast populated collagen lattice models.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150814T12:10:46+01:00
3600
2047014
true
16x9
false

Models of cell polarization and motility
ucs_sms_1633792_2030485
http://sms.cam.ac.uk/media/2030485
Models of cell polarization and motility
EdelsteinKeshet, L (University of British Columbia)
Wednesday 15th July 2015  09:00 to 10:15
Fri, 17 Jul 2015 18:23:38 +0100
Isaac Newton Institute
EdelsteinKeshet, L
b2bd79cd85fff6d19ad5d9041bd40af9
132a69806aa44d6aa2004a135079c781
db163cab6888247f8b7241411b108982
c2a58ee034d0099538774add48b2f589
EdelsteinKeshet, L (University of British Columbia)
Wednesday 15th July 2015...
EdelsteinKeshet, L (University of British Columbia)
Wednesday 15th July 2015  09:00 to 10:15
Cambridge University
4260
http://sms.cam.ac.uk/media/2030485
Models of cell polarization and motility
EdelsteinKeshet, L (University of British Columbia)
Wednesday 15th July 2015  09:00 to 10:15
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:23:38+01:00
4260
2030485
true
16x9
false

Morphogenetic models: from genetic regulatory networks to phenotypes
ucs_sms_1633792_2090901
http://sms.cam.ac.uk/media/2090901
Morphogenetic models: from genetic regulatory networks to phenotypes
Padilla, P (Universidad Nacional Autonoma de Mexico)
Tuesday 13th October 2015  11:00 to 12:30
Fri, 16 Oct 2015 17:05:27 +0100
Isaac Newton Institute
Padilla, P
ffbbbd848d679a3f29abf1bd21e59545
51b5e122bb87a415500a1b65193a2a31
26182305b9b4221674babd4e5e5faa62
e9febea48506a30d0e34d1b1c404a3d5
Padilla, P (Universidad Nacional Autonoma de Mexico)
Tuesday 13th October 2015...
Padilla, P (Universidad Nacional Autonoma de Mexico)
Tuesday 13th October 2015  11:00 to 12:30
Cambridge University
3720
http://sms.cam.ac.uk/media/2090901
Morphogenetic models: from genetic regulatory networks to phenotypes
Padilla, P (Universidad Nacional Autonoma de Mexico)
Tuesday 13th October 2015  11:00 to 12:30
We consider the spacetime dynamics given by a genetic regulatory network for the cell fate determination during flower development. Starting with experimental data, we construct a dynamical system that recovers wild type as well as mutant phenotypes. We extend this to a reactiondiffusion system that provides a model that accounts for the spatial architecture of the flower. We discuss how this approach can be generalised to other systems in developmental biology and also comment on open questions, both biological and mathematical.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151016T17:05:27+01:00
3720
2090901
true
4x3
false

Moving Cells Throughout the Embryo: A Story from the Neural Crest
ucs_sms_1633792_2078215
http://sms.cam.ac.uk/media/2078215
Moving Cells Throughout the Embryo: A Story from the Neural Crest
Kulesa, P (Stowers Institute for Medical Research)
Thursday 17th September 2015  10:00 to 11:00
Tue, 29 Sep 2015 15:38:18 +0100
Isaac Newton Institute
Kulesa Stowers, P
2e5cb601f331214561b1258ffc738e35
d89002170ad0e9a8dd4458492f4cc3a0
0d9cb29ddbd9b07474b95bb621605d33
944d059253b9e5fbdc81663750426e11
Kulesa, P (Stowers Institute for Medical Research)
Thursday 17th September...
Kulesa, P (Stowers Institute for Medical Research)
Thursday 17th September 2015  10:00 to 11:00
Cambridge University
3529
http://sms.cam.ac.uk/media/2078215
Moving Cells Throughout the Embryo: A Story from the Neural Crest
Kulesa, P (Stowers Institute for Medical Research)
Thursday 17th September 2015  10:00 to 11:00
Coauthors: Rebecca McLennan (Stowers Institute), Linus Schumacher (University of Oxford), Jason Morrison (Stowers Institute), Ruth Baker (University of Oxford), David Kay (University of Oxford), Philip Maini (University of Oxford)
The neural crest are an excellent model to study in vivo mechanisms of embryonic cell migration since cells display directed migration in discrete streams that travel long distances to precise targets. In the vertebrate head, cranial neural crest cells form bone, cartilage, neurons and glia making their migration absolutely critical to craniofacial patterning. How neural crest cells move as a coordinated population is not well understood. We have discovered that coordinated cranial neural crest migration includes lead cells with distinct cell dynamics, cell morphologies and molecular profiles consistent with maintaining directed migration. Our single cell profiing of leaders has revealed a unique molecular signature of genes highly expressed and consistent within a trailblazer subpopulation narrowly confined to the migratory front. We hypothesize that trailblazer genes serve a critical functional role for neural crest cells to establish directed migration and separate instruc tional signals are communicated to trailer cells to follow. We will discuss our modeling and experimental results.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T15:38:18+01:00
3529
2078215
true
16x9
false

Multilevel approach to cell and tissue polarity and traffic jams
ucs_sms_1633792_2140307
http://sms.cam.ac.uk/media/2140307
Multilevel approach to cell and tissue polarity and traffic jams
Grieneisen, V (John Innes Centre, Norwich)
Wednesday 9th December 2015  09:00 to 10:00
Mon, 21 Dec 2015 10:45:00 +0000
Isaac Newton Institute
Grieneisen, V
364ec9ebb7f29366ba241811497755e8
fa15e582e0736f1bbae12b76dd43e92d
d779f33fe1666c848d4394ef61292a86
72513fff85392a2a9003d278369e5a5a
Grieneisen, V (John Innes Centre, Norwich)
Wednesday 9th December 2015  09:00...
Grieneisen, V (John Innes Centre, Norwich)
Wednesday 9th December 2015  09:00 to 10:00
Cambridge University
3551
http://sms.cam.ac.uk/media/2140307
Multilevel approach to cell and tissue polarity and traffic jams
Grieneisen, V (John Innes Centre, Norwich)
Wednesday 9th December 2015  09:00 to 10:00
In this talk I wish to compare and contrast cell and tissue polarity between very diverse organisms. Computational approaches combined with molecular studies and in vivo microscopy were necessary to reveal how polarity is coordinated and linked on three different levels: on the scale of the tissue, the cellular and subcellular tissue level. At the single cell level, a spatially uniform activation and patterning of GTPases can cause polarity to emerge spontaneously, independent of spatial prepatterns or localized polarizing signals. We argue that plants and animals have inherited this same “unicellular mode” of establishing cell polarity, and that multicellular coordination has thereafter diverged using this underlying mechanism as a building block: Being capable of intracellular partitioning, neighbouring plant cells that are separated by cell wall then coordinate their polarities  through indirect cellcell coupling. This is resultant from changes in concentration level of a phytohormone, auxin, inbetween and along cells.
In the specific case of pavement cells of leaves (jigsawshaped cells with interlocking lobes and indentations), this phenomenon comes about as interdigitation, and requires the opposite response of identical neighbouring cells to the same local auxin signal in the cell wall, between the cells. Our theoretical work identifies key requirements for such indirect cellcell signalling that that gives rise to correct interdigitation. These requirements, based on known molecular interactions, can then be extrapolated to other multicellular tissues, to understand the interdependency between cell and tissue polarity.
Extrapolating these findings we further show how animal cells, capable of direct cellcell coupling, can establish, through similar principles, robust tissue coordination. In the end of our talk, I will also show how established tissue polarity in plants requires extra conditions of regulation, to avoid issues of traffic jam in relation to nutrient uptake.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:45:00+00:00
3551
2140307
true
16x9
false

Multiphase modelling of cells and tissues
ucs_sms_1633792_2034590
http://sms.cam.ac.uk/media/2034590
Multiphase modelling of cells and tissues
King, J
Thursday 23rd July 2015, 10:45 to 12:00
Fri, 24 Jul 2015 15:15:30 +0100
Isaac Newton Institute
King, J
4d0b65a4f8dea5e395100828931cf1f3
999288993ebd846ebd2929b285ae6abf
2bdee91fa7ff7c63358fd97c55aac571
e49e0baf859162c876ed5399766b9710
King, J
Thursday 23rd July 2015, 10:45 to 12:00
King, J
Thursday 23rd July 2015, 10:45 to 12:00
Cambridge University
4080
http://sms.cam.ac.uk/media/2034590
Multiphase modelling of cells and tissues
King, J
Thursday 23rd July 2015, 10:45 to 12:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:15:30+01:00
4080
2034590
true
16x9
false

Multiscale cellbased modeling of mechanical cellmatrix feedback during collective cell behavior
ucs_sms_1633792_2078371
http://sms.cam.ac.uk/media/2078371
Multiscale cellbased modeling of mechanical cellmatrix feedback during collective cell behavior
Merks, R (Centrum voor Wiskunde en Informatica [CWI], Universiteit Leiden)
Friday 18th September 2015  11:30 to 12:30
Tue, 29 Sep 2015 17:14:49 +0100
Isaac Newton Institute
Merks, R
11c29edd494e8d26978d36df1c8e2755
4ab49e7b45e4ec9e01b14a37dfbcf918
9a297259b28265a98bfe32ce537bfb1e
4b665e908951853d668c0060f19c271d
Merks, R (Centrum voor Wiskunde en Informatica [CWI], Universiteit...
Merks, R (Centrum voor Wiskunde en Informatica [CWI], Universiteit Leiden)
Friday 18th September 2015  11:30 to 12:30
Cambridge University
3600
http://sms.cam.ac.uk/media/2078371
Multiscale cellbased modeling of mechanical cellmatrix feedback during collective cell behavior
Merks, R (Centrum voor Wiskunde en Informatica [CWI], Universiteit Leiden)
Friday 18th September 2015  11:30 to 12:30
Coauthors: Elisabeth G. Rens (CWI and Leiden University), René F.M. van Oers (CWI (present address: Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands))
Apart from molecular signals, mechanical cellcell communication is key to explaining collective cell behavior biological morphogenesis. Yet, most computational models of collective cell behavior focus on chemical signaling. Endothelial cell cultures on compliant substrates are a good model system of mechanical signaling during morphogenesis. Depending on the stiffness and other biophysical and chemical properties of the substrates, the endothelial cells can form blood vessellike structures, including vascular networks and sprouts. Here we discuss a hybrid Cellular Potts and finite element computational model, in which a limited set of biologically plausible rules describing the mechanical cellECM interactions suffices for reproducing aspects of endothelial cell behavior at the single cell, pairwise and collective scale. The model includes the contractile forces that endothelial cells exert on the ECM, the resulting strains in the extracellular matrix, and the cellular resp onse to the strains. The simulations reproduce the behavior of individual endothelial cells, the interactions of endothelial cell pairs in compliant matrices, and network formation and sprouting from endothelial spheroids. We will conclude by showing how the mechanical interactions between cells and the extracellular matrix amplify the dynamic response of tissue organization to external strain. This response offers a potential route by which large scale strains in growing embryos can control the cellular structure of tissues.
Related Links
http://biomodel.project.cwi.nl  Web site of group
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003774  Open access paper on previous work on this topic
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T17:14:49+01:00
3600
2078371
true
16x9
false

Multiscale modelling for cell motility
ucs_sms_1633792_2140511
http://sms.cam.ac.uk/media/2140511
Multiscale modelling for cell motility
Preziosi, L (Politecnico di Torino)
Thursday 10th December 2015  10:00 to 11:00
Mon, 21 Dec 2015 11:13:50 +0000
Isaac Newton Institute
Preziosi, L
375c137ed41247912bb7d4e4db3353c3
6f9bc366f5bc2517643ede14e584e683
e9f69d9389a548a2f22423738e1aec1f
7e0392c2a7ca72a35b01d722de27da3a
Preziosi, L (Politecnico di Torino)
Thursday 10th December 2015  10:00 to...
Preziosi, L (Politecnico di Torino)
Thursday 10th December 2015  10:00 to 11:00
Cambridge University
2734
http://sms.cam.ac.uk/media/2140511
Multiscale modelling for cell motility
Preziosi, L (Politecnico di Torino)
Thursday 10th December 2015  10:00 to 11:00
Several problems regarding cell motility and morphogenesis are characterized by the contemporary presence of cells that behave as single entities and cells that follow and cluster around them. From the mathematical point of view, describing such phenomena requires the development of mathematical models in which virtual cells can switch from a discrete to a continuous description. Keeping this in mind, the talk aims at presenting some ideas on how to do that, making for instance use of measure theory or introducing the concept of bubble functions.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:13:50+00:00
2734
2140511
true
16x9
false

Multiscale modelling of cancer growth and treatment
ucs_sms_1633792_2034583
http://sms.cam.ac.uk/media/2034583
Multiscale modelling of cancer growth and treatment
Chaplain, M (University of St Andrews)
Thursday 23rd July 2015, 09:00 to 10:15
Fri, 24 Jul 2015 15:20:47 +0100
Isaac Newton Institute
Chaplain, M
020f02cdbf86d319a7751c8886ae2252
21cdee5b8ec050b029815b32d9e5404a
3b2c42a668a9f7f050ff1f8fb21cb158
696d11f415bc4add7f4959b84d059f14
Chaplain, M (University of St Andrews)
Thursday 23rd July 2015, 09:00 to 10:15
Chaplain, M (University of St Andrews)
Thursday 23rd July 2015, 09:00 to 10:15
Cambridge University
4440
http://sms.cam.ac.uk/media/2034583
Multiscale modelling of cancer growth and treatment
Chaplain, M (University of St Andrews)
Thursday 23rd July 2015, 09:00 to 10:15
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:20:47+01:00
4440
2034583
true
16x9
false

Multiscale Modelling of CellECM interaction
ucs_sms_1633792_2030513
http://sms.cam.ac.uk/media/2030513
Multiscale Modelling of CellECM interaction
Preziosi, L (Politecnico di Torino)
Thursday 16th July 2015, 09:00 to 10:15
Fri, 17 Jul 2015 18:34:32 +0100
Isaac Newton Institute
Preziosi, L
0e6488659eba4f6cf902081ec834ac1f
838c6492c12e1a09d0ea52003e307818
47d547583301cbd0743f53deace47fa4
13d4ba1032df99896ffffe8fb77cea18
Preziosi, L (Politecnico di Torino)
Thursday 16th July 2015, 09:00 to 10:15
Preziosi, L (Politecnico di Torino)
Thursday 16th July 2015, 09:00 to 10:15
Cambridge University
4260
http://sms.cam.ac.uk/media/2030513
Multiscale Modelling of CellECM interaction
Preziosi, L (Politecnico di Torino)
Thursday 16th July 2015, 09:00 to 10:15
Cellextracellular matrix interaction and the mechanical properties of cell nucleus have been demonstrated to play a fundamental role in cell movement across fibre networks and microchannels. In the talk, we will describe several mathematical models dealing with such a problem, starting from modelling cell adhesion mechanics to the inclusion of influence of nucleus stiffness in the motion of cells. An energetic approach is used in order to obtain a necessary condition for which cells enter cylindrical structures. The nucleus of the cell is treated either (i) as an elastic membrane surrounding a liquid droplet or (ii) as an incompressible elastic material with NeoHookean constitutive equation. The results obtained highlight the importance of the interplay between mechanical deformability of the nucleus and the capability of the cell to establish adhesive bonds.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:34:32+01:00
4260
2030513
true
16x9
false

Multiscale modelling of pressure and flow in the pulmonary circulation
ucs_sms_1633792_2140668
http://sms.cam.ac.uk/media/2140668
Multiscale modelling of pressure and flow in the pulmonary circulation
Hill, N (University of Glasgow)
Friday 11th December 2015  10:00 to 11:00
Mon, 21 Dec 2015 11:33:19 +0000
Isaac Newton Institute
Hill, N
73a501197806e6898698e31f9be7ec21
41ee431cffadadeea2cc41e5f5a3c1dd
b7428d93e8febfa1050563d63c7a3c29
4c312a520852ddeebdefc2f7362c34d9
Hill, N (University of Glasgow)
Friday 11th December 2015  10:00 to 11:00
Hill, N (University of Glasgow)
Friday 11th December 2015  10:00 to 11:00
Cambridge University
3600
http://sms.cam.ac.uk/media/2140668
Multiscale modelling of pressure and flow in the pulmonary circulation
Hill, N (University of Glasgow)
Friday 11th December 2015  10:00 to 11:00
A multiscale computational model has been developed to predict flow and pressure in the pulmonary circulation, in which the flow and pressure in the smaller blood vessels are described using linearised equations in pairs of asymmetric structured trees joined at the roots. The geometric and elastic properties of all the blood vessels are described by physiological parameters. Magnetic resonance imaging (MRI) is used to determine the geometry of the large pulmonary arteries and veins, and to measure the cardiac output from the right ventricle. The flow in the large blood vessels is solved using a LaxWendroff scheme, and the admittances of the structured trees provide the boundary conditions linking each large artery to its respective large vein. The model predicts flow and pressure in both the large and small vessels down to 50\, m in radius, providing important data about the local physiological environment experienced by tissues and cells.
The results of simulating various pathological conditions are in agreement with clinical observations, showing that the model has potential for assisting with diagnosis and treatment of circulatory diseases within the lung. We use wave intensity analysis to study the propagation of forward and backward, compression and decompression waves in our model. The approximations for the pulse wave velocity used in experiments on wave intensity analysis are assessed, and reflected waves lower the peak pressure in the right ventricle.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:33:19+00:00
3600
2140668
true
16x9
false

NonMarkovian ReactionTransport: Modelling Biological Invasions
ucs_sms_1633792_2059302
http://sms.cam.ac.uk/media/2059302
NonMarkovian ReactionTransport: Modelling Biological Invasions
Mendez, V (Universitat Autònoma de Barcelona)
Thursday 20 August 2015, 11:0012:00
Tue, 01 Sep 2015 10:59:08 +0100
Isaac Newton Institute
Mendez, V
2ee65c9a750170a79b4591fb81ab313d
0cf36fdcaa193c11bc145aadefe01647
1f737e81cd1f441518e832ef93fc4aa1
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Mendez, V (Universitat Autònoma de Barcelona)
Thursday 20 August 2015,...
Mendez, V (Universitat Autònoma de Barcelona)
Thursday 20 August 2015, 11:0012:00
Cambridge University
3538
http://sms.cam.ac.uk/media/2059302
NonMarkovian ReactionTransport: Modelling Biological Invasions
Mendez, V (Universitat Autònoma de Barcelona)
Thursday 20 August 2015, 11:0012:00
A common key feature of many biological invasions is the existence of rest phases during which individuals reproduce. Since this process alternates with phases of movement it is necessary to make use of a general description where both processes are coupled, i.e., cannot occur separately. However, some recent studies propose reactiondiffusion equations that lead to behaviours that cannot be physically accepted. In this talk I will show the reasons why these equations cannot be used and will present mesoscopic models adequate for biological invasions modelling.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150901T10:59:08+01:00
3538
2059302
true
16x9
false

Nonlocal models for interaction driven cell movement
ucs_sms_1633792_2140691
http://sms.cam.ac.uk/media/2140691
Nonlocal models for interaction driven cell movement
Gerisch, A (Technische Universität Darmstadt)
Friday 11th December 2015  11:30 to 12:30
Mon, 21 Dec 2015 11:33:36 +0000
Isaac Newton Institute
Gerisch, A
16b28c9907dfffcc58f8f94af79a9b71
aa792868d0a86c4c0330f60ed4e94762
aa252de3ef7c840621f2b9e36043f06f
6768a9a8fcb77b2035222e27fac5e4a8
Gerisch, A (Technische Universität Darmstadt)
Friday 11th December 2015 ...
Gerisch, A (Technische Universität Darmstadt)
Friday 11th December 2015  11:30 to 12:30
Cambridge University
3562
http://sms.cam.ac.uk/media/2140691
Nonlocal models for interaction driven cell movement
Gerisch, A (Technische Universität Darmstadt)
Friday 11th December 2015  11:30 to 12:30
Authors: A. Gerisch, K.J. Painter, J.M. Bloomfield, J.A. Sherratt
Instructing others to move is fundamental for many populations, whether animal or cellular. Often such commands are transmitted by contact, such that an instruction is relayed directly from signaller to receiver: for cells, this can occur via receptor–ligand mediated interactions at their membranes, potentially at a distance if a cell extends long filopodia. Given that commands ranging from attractive to repelling can be transmitted over variable distances and between cells of the same (homotypic) or different (heterotypic) type, these mechanisms can clearly have a significant impact on the organisation of a tissue. In this talk we consider nonlocal models based on integroPDEs to model contact based cell movement. We describe some specific applications and highlight the mathematical and numerical challenges that the models present.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:33:37+00:00
3562
2140691
true
16x9
false

Osmosis, Electrophysiology and Cell Movement
ucs_sms_1633792_2030520
http://sms.cam.ac.uk/media/2030520
Osmosis, Electrophysiology and Cell Movement
Mori, Y (University of Minnesota)
Thursday 16th July 2015, 10:45 to 12:00
Fri, 17 Jul 2015 18:41:11 +0100
Isaac Newton Institute
Mori, Y
720603c425f3c35d8023798b54ad2fbc
f1c1a47b7adf8aaadc46323d5e732f1d
2f36ae876fc471968c06bdfa291fd16e
49273191fb9087c76ced168deaeb2faa
Mori, Y (University of Minnesota)
Thursday 16th July 2015, 10:45 to 12:00
Mori, Y (University of Minnesota)
Thursday 16th July 2015, 10:45 to 12:00
Cambridge University
5040
http://sms.cam.ac.uk/media/2030520
Osmosis, Electrophysiology and Cell Movement
Mori, Y (University of Minnesota)
Thursday 16th July 2015, 10:45 to 12:00
Water movement in the biological tissue is controlled primarily by osmosis, and the primary osmolytes are ions (Na, K, Cl etc). It is then natural to think that electrophysiology is in some way related to cell movement. This indeed seems to be the case; there is mounting evidence that ion channels and aquaporins play an important role in cell movement. In this talk, we will first review some classical facts about electrophysiology, focusing on its role in cell volume control. We will also discuss the classical subject of fluid secretion/absorption in epithelial systems, and compare this with recent work on a mode of cell movement that seems to be predominantly osmotic. We will then present a mathematical framework that couples electrophysiology, osmosis and cell mechanics in a natural way that allows for the study of this interplay. We will show preliminary 2D computational results of a deforming model cell moving using osmotic forces.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:41:11+01:00
5040
2030520
true
16x9
false

Parallel multigrid methods for parabolic partial differential equations and applications
ucs_sms_1633792_2083063
http://sms.cam.ac.uk/media/2083063
Parallel multigrid methods for parabolic partial differential equations and applications
Yang, FW (University of Sussex)
Thursday 1st October 2015  11:00 to 12:30
Tue, 06 Oct 2015 14:50:19 +0100
Isaac Newton Institute
Yang, FW
500abf765d42d3443c01f96397da4321
c982169d797f35348ddfb4703c9e5a36
2dce74c9fb9efc4dab3f460bf9ba2430
18b8829497f348cf5272088b3aa200f6
Yang, FW (University of Sussex)
Thursday 1st October 2015  11:00 to 12:30
Yang, FW (University of Sussex)
Thursday 1st October 2015  11:00 to 12:30
Cambridge University
4020
http://sms.cam.ac.uk/media/2083063
Parallel multigrid methods for parabolic partial differential equations and applications
Yang, FW (University of Sussex)
Thursday 1st October 2015  11:00 to 12:30
In the first part of the talk, I will give the audience an overview of a socalled geometric multigrid. I must extend the discussion to include advanced computational techniques for better efficiency, namely adaptive mesh refinements, parallelisation through domain decomposition and adaptive timestepping.
In the second part, I will describe how do we apply these techniques to mathematical models of partial differential equations. We will have a look at a thin film model of droplet spreading. Then we move on to an optimal control model for whole cell tracking. I will also discuss some robust techniques of greater efficiency for general semilinear optimal control models. The whole cell tracking is closely related to the cell biology and I hope to end the talk with some discussions to its further practical use.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151006T14:50:19+01:00
4020
2083063
true
16x9
false

Parametric finite element methods for twophase flow and dynamic
ucs_sms_1633792_2033239
http://sms.cam.ac.uk/media/2033239
Parametric finite element methods for twophase flow and dynamic
Nalbant, P (Universität DuisburgEssen)
Tuesday 21st July 2015, 15:15 to 16:30
Wed, 22 Jul 2015 16:48:19 +0100
Isaac Newton Institute
Nalbant, P
8d37aa08ad7193316646b662756a1043
6bbd00a78e4933cf1342238619818855
b82cbcca630800132e9cebf1032eab1c
e4f67007ce34d292e30b9c97da29e775
Nalbant, P (Universität DuisburgEssen)
Tuesday 21st July 2015, 15:15 to 16:30
Nalbant, P (Universität DuisburgEssen)
Tuesday 21st July 2015, 15:15 to 16:30
Cambridge University
3720
http://sms.cam.ac.uk/media/2033239
Parametric finite element methods for twophase flow and dynamic
Nalbant, P (Universität DuisburgEssen)
Tuesday 21st July 2015, 15:15 to 16:30
In this talk I will discuss recent advances in the numerical analysis of fronttracking methods for two moving interface problems. In the first part of the talk I will concentrate on a parametric finite element approximation of twophase flow. Here two fluids evolve in a domain, separated by an interface. Stress balance conditions on the interface lead to surface tension terms involving curvature. We employ a variational approximation of curvature that originates from the numerical approximation of geometric evolution equations, such as mean curvature flow. The arsising finite element approximation of twophase flow can be shown to be unconditionally stable. In the second part of the talk, building on the concepts introduced in the first part, I will present a numerical method for the approximation of dynamic biomembranes. Once again two phases of fluid are separated by an interface, but here the interface is endowed with an elastic curvature energy. This models the properties of the lipid bilayer structure of the biomembrane's cell walls. Combining ideas on the numerical approximation of Willmore flow, twophase flow and surface PDEs on an evolving manifold we are able to introduce a stable parametric finite element method for the evolution of biomembranes.
Suggested review articles:
Deckelnick, K., Dziuk, G., and Elliott, C. M. (2005). Computation of geometric partial differential equations and mean curvature flow. Acta Numer., 14, 139232.Seifert, U. (1997). Configurations of fluid membranes and vesicles. Adv. Phys., 46, 13137.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150722T16:48:19+01:00
3720
2033239
true
16x9
false

Parametric finite element methods for twophase flow and dynamic biomembranes
ucs_sms_1633792_2032518
http://sms.cam.ac.uk/media/2032518
Parametric finite element methods for twophase flow and dynamic biomembranes
Nürnberg, R (Imperial College London)
Friday 17th July 2015, 09:00 to 10:15
Tue, 21 Jul 2015 13:17:39 +0100
Isaac Newton Institute
Nürnberg, R
6cb809ff900d683506546499a7feffe9
6fc46f9ba9c8accddacf7ad6732b3f86
225c36a9f447358125ddb56d67536c20
684381efc773741f03ac9cb8b56f643a
Nürnberg, R (Imperial College London)
Friday 17th July 2015, 09:00 to 10:15
Nürnberg, R (Imperial College London)
Friday 17th July 2015, 09:00 to 10:15
Cambridge University
3720
http://sms.cam.ac.uk/media/2032518
Parametric finite element methods for twophase flow and dynamic biomembranes
Nürnberg, R (Imperial College London)
Friday 17th July 2015, 09:00 to 10:15
In this talk I will discuss recent advances in the numerical analysis of fronttracking methods for two moving interface problems. In the first part of the talk I will concentrate on a parametric finite element approximation of twophase flow. Here two fluids evolve in a domain, separated by an interface. Stress balance conditions on the interface lead to surface tension terms involving curvature. We employ a variational approximation of curvature that originates from the numerical
approximation of geometric evolution equations, such as mean curvature flow. The arsising finite element approximation of twophase flow can
be shown to be unconditionally stable. In the second part of the talk, building on the concepts introduced in the first part, I will present a numerical method for the
approximation of dynamic biomembranes. Once again two phases of fluid are separated by an interface, but here the interface is endowed with
an elastic curvature energy. This models the properties of the lipid bilayer structure of the biomembrane's cell walls. Combining ideas on
the numerical approximation of Willmore flow, twophase flow and surface PDEs on an evolving manifold we are able to introduce a stable
parametric finite element method for the evolution of biomembranes.
Suggested review articles: Deckelnick, K., Dziuk, G., and Elliott, C. M. (2005). Computation of geometric partial differential equations and mean curvature flow.
Acta Numer., 14, 139232. Seifert, U. (1997). Configurations of fluid membranes and vesicles.Adv. Phys., 46, 13137.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150721T13:17:39+01:00
3720
2032518
true
16x9
false

Pattern formation by molecular motors in cellular protrusions
ucs_sms_1633792_2140709
http://sms.cam.ac.uk/media/2140709
Pattern formation by molecular motors in cellular protrusions
Yochelis, A (BenGurion University)
Friday 11th December 2015  13:30 to 14:15
Mon, 21 Dec 2015 11:31:06 +0000
Isaac Newton Institute
Yochelis, A
30fbd7b9dd37f62982b80f441222ba50
40c2ad576e21b6056fca94a29452ba93
2ee4b0c7c5e700016aae16a6af08e34c
1125fb4442f3eff301a067cd1e45a325
Yochelis, A (BenGurion University)
Friday 11th December 2015  13:30 to 14:15
Yochelis, A (BenGurion University)
Friday 11th December 2015  13:30 to 14:15
Cambridge University
2994
http://sms.cam.ac.uk/media/2140709
Pattern formation by molecular motors in cellular protrusions
Yochelis, A (BenGurion University)
Friday 11th December 2015  13:30 to 14:15
Coauthors: S. Ebrahim (NIH, US), B. Millis (NIH, US), R. Cui (NIH, US), B. Kachar (NIH, US), M. Naoz (Weizmann Institute of Science, Israel), N. S. Gov (Weizmann Institute of Science, Israel)
Actinbased cellular protrusions are an ubiquitous feature of cells, performing a variety of critical functions ranging from cellcell communication to cell motility. The formation and maintenance of these protrusions relies on the transport of proteins via myosin motors, to the protrusion tip. While tipdirected motion leads to accumulation of motors (and their molecular cargo) at the protrusion tip, it is observed that motors also form rearward moving, periodic and isolated aggregates. Not only that these aggregates are apparently important to the recycling of the motors but also their origins and mechanisms are open puzzles. Motivated by novel experiments, a mass conserving nonlinear reactiondiffusionadvection model is proposed. Analysis of the model provides insights into pattern selection mechanisms, i.e., how local and global bifurcations, and boundary conditions lead to emergence of pulses and traveling waves. These pattern selection mechanisms are found not only to qualitatively agree with empirical observations but open new vistas to the transport phenomena by molecular motors in general.
Related Links
http://www.bgu.ac.il/~yochelis/  Homepage of Arik Yochelis
http://dx.doi.org/10.1038/srep13521  Reference
http://www.nature.com/articleassets/npg/srep/2015/150903/srep13521/extref/srep13521s2.avi  Supplementary experimental movie
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:31:06+00:00
2994
2140709
true
16x9
false

Patterns in Polarisable Elastic Active Layers
ucs_sms_1633792_2059309
http://sms.cam.ac.uk/media/2059309
Patterns in Polarisable Elastic Active Layers
Pismen, L (Technion  Israel Institute of Technology)
Tuesday 25 August 2015, 11:0012:00
Tue, 01 Sep 2015 11:12:20 +0100
Isaac Newton Institute
Pismen, L
65f03c6aa8c80da6012eb7c5b289c09e
f0ec5aafdf102372f0adc2feb90ba9f5
1ad8fca117b2ee431b07a49f7a1c71d4
0904af7db9b8a22f443a5584f58f7005
Pismen, L (Technion  Israel Institute of Technology)
Tuesday 25 August 2015,...
Pismen, L (Technion  Israel Institute of Technology)
Tuesday 25 August 2015, 11:0012:00
Cambridge University
4020
http://sms.cam.ac.uk/media/2059309
Patterns in Polarisable Elastic Active Layers
Pismen, L (Technion  Israel Institute of Technology)
Tuesday 25 August 2015, 11:0012:00
I explore a class of macroscopic continuous models with feedback interactions inducing spontaneous vector or nematic polarisation and mechanical deformation of elastic active media. Linear stabilityanalysis predicts, depending on the sign of feedback interaction coefficients, either monotonic or oscillatory instability of the homogeneous isotropic state. In the former case, the emerging pattern undergoes a slow coarsening process but permanent polarity may emerge when the system is topologically constrained. Oscillatory instabilities arise in active systems on a finite wavelength, and lead to complex wave patterns. Transition to a deformed polarised state may be frustrated in constrained geometry but leads to boundary undulations in freeboundary settings.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150901T11:12:20+01:00
4020
2059309
true
16x9
false

PDEs on evolving domains
ucs_sms_1633792_2034549
http://sms.cam.ac.uk/media/2034549
PDEs on evolving domains
Elliott, C
Wednesday 22nd July 2015, 09:00 to 10:15
Fri, 24 Jul 2015 15:32:13 +0100
Isaac Newton Institute
Elliott, C
6c18b760ce925eb63dfc4ba33f371134
505cd032802ef44c10293b7ceb789aef
7794651b1d778977ac173f6a21169224
55f640375cc4ff5444d1f2e054044bd4
Elliott, C
Wednesday 22nd July 2015, 09:00 to 10:15
Elliott, C
Wednesday 22nd July 2015, 09:00 to 10:15
Cambridge University
5340
http://sms.cam.ac.uk/media/2034549
PDEs on evolving domains
Elliott, C
Wednesday 22nd July 2015, 09:00 to 10:15
Recently with Aphonse and Stinner we have presented an abstract framework for treating the theory of well posedness of solutions to abstract parabolic partial differential equations on evolving Hilbert spaces. This theory is applicable to variational for mulations of PDEs on evolving spatial domains including moving hyper surfaces. We formulate an appropriate time derivative on evolving spaces called the material derivative and define a weak material derivative in analogy with the usual time derivative in fixed domain problems; our set ting is abstract and not restricted to evolving domains or surfaces. Then we show wellposedness to a certain class of parabolic PDEs under some assumptions on the parabolic operator and the data. Specifically, we study in turn a surface heat equation, an equation posed on a bulk domain, a novel coupled bulksurface system and an equation with a dynamic boundary condition. In this talk we give some background to applications in cell biology. We describe how the theory may be used in the development and numerical analysis of evolving surface finite element methods and give some computational examples involving the coupling of surface evolution to processes on the surface. We indicate how this approach may work for PDEs on general evolving domains. We will discuss briefly surface finite elements for finding surfaces in the context of models for biomembranes. We will indicate how other approaches might be applicable.
Background material: K. P. Deckelnick, G. Dziuk and C. M. Elliott Computation of Geometric PDEs and Mean Curvature Flow Acta Numerica (2005) 139–232
G. Dziuk and C. M. Elliott Finite element methods for surface partial differential equations Acta Numerica (2013) 289–396
See:https://scholar.google.co.uk/citations?hl=en&user=uViOnZ4AAAAJ&view_op=list_works&sortby=pubdate
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:32:13+01:00
5340
2034549
true
16x9
false

Phase field models for multiphase flow with applications to cell motility
ucs_sms_1633792_2033232
http://sms.cam.ac.uk/media/2033232
Phase field models for multiphase flow with applications to cell motility
Aland, S (Technische Universität Dresden)
Tuesday 21st July 2015, 13:30 to 14:45
Wed, 22 Jul 2015 17:02:59 +0100
Isaac Newton Institute
Aland, S
fdb933f4c6b03b5d30efa4d810df10e1
44f190a92f1fa600143055f8e33fbd30
8faab67f46f4837ce3bd24c9e9307bab
f90dc54afbb4ffa14b97963d212bb33e
Aland, S (Technische Universität Dresden)
Tuesday 21st July 2015, 13:30 to...
Aland, S (Technische Universität Dresden)
Tuesday 21st July 2015, 13:30 to 14:45
Cambridge University
4680
http://sms.cam.ac.uk/media/2033232
Phase field models for multiphase flow with applications to cell motility
Aland, S (Technische Universität Dresden)
Tuesday 21st July 2015, 13:30 to 14:45
Coauthors: Wieland Marth (TU Dresden, Germany), Axel Voigt (TU Dresden, Germany) Many processes in biological cells can be described as multiphase flow systems. In this lecture I will introduce the diffuse interface model for such systems. One advantage is the simple coupling to additional physical effects. In particular, I will show how to account for species concentrations in the bulk phases and on the interface. The approach will be illustrated by numerical simulation of endocytosis and cell motility.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150722T17:02:59+01:00
4680
2033232
true
16x9
false

Physical theories of cell mechanics
ucs_sms_1633792_2029320
http://sms.cam.ac.uk/media/2029320
Physical theories of cell mechanics
Safran, S (Weizmann Institute of Science)
Tuesday 14th July 2015, 10:30  11:30
Wed, 15 Jul 2015 19:02:03 +0100
Isaac Newton Institute
Safran, S
3a4a43355912d81ee4e519f844899df0
2d15f999d8aa6fec7d91e492b38faf57
f922777490957b3e5c930cb0157bbfc3
510155310924bfc5f6fa85c2330c7074
Safran, S (Weizmann Institute of Science)
Tuesday 14th July 2015, 10:30  11:30
Safran, S (Weizmann Institute of Science)
Tuesday 14th July 2015, 10:30  11:30
Cambridge University
4440
http://sms.cam.ac.uk/media/2029320
Physical theories of cell mechanics
Safran, S (Weizmann Institute of Science)
Tuesday 14th July 2015, 10:30  11:30
Coauthors: Ohad Cohen (Weizmann Institute of Science, Rehovot, Israel), Kinjal Dasbiswas (Weizmann Institute of Science, Rehovot, Israel), Xinpeng Xu (Weizmann Institute of Science, Rehovot, Israel)
Cell contractility at either the coarsegrained level of an entire cell or at the subcellular level of individual actomyosin fibers, can be understood using the concept of elastic force dipoles. These dipoles interact via their mutual deformations of the surrounding viscoelastic medium which can be either the extracellular matrix (in the case of cells modeled as force dipoles) or the internal, cellular cytoskeleton (in the case of actomyosin fibers within the cell). The theory of these elastically mediated interactions combined with the unique "living" nature of cells (implying that the activity of these dipoles is nonequilibrium and energy consuming) allows us to understand the organization and order of actomyosin fibers within the cytoskeleton of a single cell or among contractile cells in systems of nonmotile and adherent cells. We present the general theory of elastic interactions in the context of actomyosin activity with examples that demonstrate its utility in understanding experiments on cytoskeletal alignment in stem cells that differentiate into muscle cells, the structure and beating of cardiomyocytes, very longranged cellcell interactions in fibrous elastic matrices, and elastically controlled diffusion of biomolecules that trigger development in embryos.
Related Links
http://www.weizmann.ac.il/fluids/Safran/publications.html  Safran Publications
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T19:02:03+01:00
4440
2029320
true
16x9
false

Quantitative Biology Research at Astra Zeneca
ucs_sms_1633792_2140487
http://sms.cam.ac.uk/media/2140487
Quantitative Biology Research at Astra Zeneca
Stott, J (AstraZeneca, UK)
Wednesday 9th December 2015  15:50 to 16:20
Mon, 21 Dec 2015 10:58:23 +0000
Isaac Newton Institute
Stott, J
1dc4bbab901781bd42292644efb52caf
02c470cbfae978bc4ba6a3b9734a69e3
ae1ac93094d79b049392a84d1d31280d
a7db7c85efb199c58b5d1d6294bf8de0
Stott, J (AstraZeneca, UK)
Wednesday 9th December 2015  15:50 to 16:20
Stott, J (AstraZeneca, UK)
Wednesday 9th December 2015  15:50 to 16:20
Cambridge University
1990
http://sms.cam.ac.uk/media/2140487
Quantitative Biology Research at Astra Zeneca
Stott, J (AstraZeneca, UK)
Wednesday 9th December 2015  15:50 to 16:20
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:58:23+00:00
1990
2140487
true
16x9
false

Quantitative imaging of migrating cells in vitro and in living tissues
ucs_sms_1633792_2034604
http://sms.cam.ac.uk/media/2034604
Quantitative imaging of migrating cells in vitro and in living tissues
Möhl, C
Thursday 23rd July 2015, 15:15 to 16:30
Fri, 24 Jul 2015 15:32:23 +0100
Isaac Newton Institute
Möhl, C
d43d1ac6aaaaf752b5f0e8cc38118bd2
c6219ad032e3dd677a43b3eb7edb4bf4
958144f84691ff5d2f32de96c70ee855
9686a1e8579b291e687994ce4edb0237
Möhl, C
Thursday 23rd July 2015, 15:15 to 16:30
Möhl, C
Thursday 23rd July 2015, 15:15 to 16:30
Cambridge University
4680
http://sms.cam.ac.uk/media/2034604
Quantitative imaging of migrating cells in vitro and in living tissues
Möhl, C
Thursday 23rd July 2015, 15:15 to 16:30
During the past 20 years, imaging of specific proteins in living biological systems has become one of the most powerful techniques to investigate processes of life on the micro scale. By optical imaging of genetically encoded fluorescent reporters, the localization and dynamics of functional proteins can directly be observed in artificial cell culture systems as well as in whole animals. For studying the process of cell migration specific parts of the cytoskeleton (e.g. actin bundles or substrate adhesion sites) can be recorded in timelapse movies. However, due to technical limitations it is not feasible to observe multiple target structures simultaneously in one experiment. Thus, the interplay of multiple cellular components such as the contractile actinmyosin network and forcetransducing adhesion sites is difficult to investigate. I will discuss opportunities and limitations of optical imaging for studying cell migration by examples from my work on single cell migration as well as collective cell migration during embryonic development. Amongst others, I will present methods how to quantify cellular dynamics with image processing methods and how to integrate heterogeneous data from multiple independent observations to one consistent picture.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150724T15:32:23+01:00
4680
2034604
true
16x9
false

Rheology of actomyosin and emergent mechanical properties of cells
ucs_sms_1633792_2078364
http://sms.cam.ac.uk/media/2078364
Rheology of actomyosin and emergent mechanical properties of cells
Etienne, J (CNRS [Centre national de la recherche scientifique], Université de Grenoble)
Friday 18th September 2015  10:00 to 11:00
Tue, 29 Sep 2015 16:55:53 +0100
Isaac Newton Institute
Etienne, J
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Etienne, J (CNRS [Centre national de la recherche scientifique], Université de...
Etienne, J (CNRS [Centre national de la recherche scientifique], Université de Grenoble)
Friday 18th September 2015  10:00 to 11:00
Cambridge University
3083
http://sms.cam.ac.uk/media/2078364
Rheology of actomyosin and emergent mechanical properties of cells
Etienne, J (CNRS [Centre national de la recherche scientifique], Université de Grenoble)
Friday 18th September 2015  10:00 to 11:00
Coauthors: Jonathan Fouchard (Univ. ParisDiderot (now UCL)), Démosthène Mitrossilis (Univ. ParisDiderot (now Inst. Curie)), Nathalie Bufi (Univ. ParisDiderot (now Brain & Spine Inst., Paris), Pauline DurandSmet (Univ. ParisDiderot (now Caltech)), Atef Asnacios (Univ. ParisDiderot)
Living cells adapt and respond actively to the mechanical properties of their environment. In addition to biochemical mechanotransduction, evidence exists for a purely mechanical sensitivity to the stiffness of the surroundings at the cellscale. Using a minimal model that describes the collective behaviour of actin, actin crosslinkers and myosin, we show that the mechanosensitive response of cells spreading between distant elastic microplates is entirely and quantitatively predicted by the behaviour of the actomyosin cortex as a contractile viscoelastic fluid.
During this talk, I will present these results [1]:  A simple kinetic model for actin and myosin interaction, leading to a viscoelastic liquid rheology including a source term for myosin action.  The analytical resolution of the statics and dynamics of a thin shell of such a viscoelastic contractile material, which allow to predict quantitatively the behaviour of cells during parallel plates experiments [24].  The significance of this for cell mechanics: the phenomenon of mechanosensitivity can be explained by an intrinsic emergent mechanical behaviour of actomyosin, and the retrograde flow of actin interpreted as a way of regulating cell size.  An analysis of the energy budget of actomyosin during cell contraction: three different mechanisms of dissipation can be identified and quantified.  A comparison of these dissipation mechanisms with the case of the contraction of a whole muscle, as studied experimentally by A. V. Hill [5] and modelled by A. F. Huxley [6].
[1] J. Étienne, et al. Proc. Natl. Acad. Sci. USA, 112:27402745, 2015. [2] D. Mitrossilis et al. Proc. Natl. Acad. Sci. USA, 106:1824318248, 2009. [3] D. Mitrossilis et al. Proc. Natl. Acad. Sci. USA, 107:1651816523, 2010. [4] K. D. Webster et al. PLoS ONE, 6:e17807, 2011. [5] A. V. Hill. Proc. R. Soc. Lond. B, 126:136195, 1938. [6] A. F. Huxley. Prog. Biophys. Biophys. Chem., 7:255318, 1957.
Related Links
http://wwwliphy.ujfgrenoble.fr/pagesperso/etienne/liquidmotors/  Webpage of Etienne et al 2015 paper
http://wwwliphy.ujfgrenoble.fr/jocelynetienne  J Etienne's page
http://www.msc.univparisdiderot.fr/~atef_asnacios/index_en.html  A Asnacios's page
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T16:55:53+01:00
3083
2078364
true
16x9
false

Selfcalibration of structural engineering in plant shoots
ucs_sms_1633792_2078387
http://sms.cam.ac.uk/media/2078387
Selfcalibration of structural engineering in plant shoots
Nakayama, N (University of Edinburgh)
Friday 18th September 2015  14:15 to 15:00
Tue, 29 Sep 2015 17:21:17 +0100
Isaac Newton Institute
Nakayama, N
4c8c4c1b9af5ff29a0c5761f838ca3fc
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7574693f063b1137ffa14e19c908a368
Nakayama, N (University of Edinburgh)
Friday 18th September 2015  14:15 to...
Nakayama, N (University of Edinburgh)
Friday 18th September 2015  14:15 to 15:00
Cambridge University
2956
http://sms.cam.ac.uk/media/2078387
Selfcalibration of structural engineering in plant shoots
Nakayama, N (University of Edinburgh)
Friday 18th September 2015  14:15 to 15:00
The shapes of living organisms are determined not only by their physiological function, but also by the engineering stability of their body. Recently mechanical parameters of tissues are emerging as important regulators of multicellular development; both intrinsic and external mechanical stimuli can impact cell division, growth, and differentiation. This is particularly the case in plants, which can adjust their morphology and anatomy according to the mechanical demands imposed upon them. How plants sense and respond to mechanical stimuli to sustain their structural stability is an exciting question that remains largely unexplored. My group aims to comprehend mechanically induced developmental plasticity in the model plant Arabidopsis, through a highly integrative programme encompassing biochemistry and systems biology to computer simulation and material science analyses. Selfstabilisation of plant shoot engineering is mediated by the accumulation dynamics of phytohormone au xin, a major morphogen in plants that is sensitive to mechanical strain and stress. We are currently developing a microfluidics platform to characterise mechanosensing and immediate responses at the cellular level. Since engineering stability of plants is also crucial to agriculture, we are also exploring improvement of cereal grain production via mechanical stimulation. Specifically, we are investigating the molecular and engineering mechanisms behind a longstanding agricultural practice in Japan called mugifumi, which reduces structural failure of wheat and barley plants by simple mechanical treatments.
Related Links
http://www.bioformfunction.org  Lab website
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T17:21:17+01:00
2956
2078387
true
16x9
false

Selforganizatin of the actin cytoskeleton
ucs_sms_1633792_2029334
http://sms.cam.ac.uk/media/2029334
Selforganizatin of the actin cytoskeleton
Bershadsky, A
Tuesday 14th July 2015, 14:30  15:30
Wed, 15 Jul 2015 19:09:22 +0100
Isaac Newton Institute
Bershadsky, A
dedf39f54ec60223fa0c2ed2b94b60e7
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Bershadsky, A
Tuesday 14th July 2015, 14:30  15:30
Bershadsky, A
Tuesday 14th July 2015, 14:30  15:30
Cambridge University
4200
http://sms.cam.ac.uk/media/2029334
Selforganizatin of the actin cytoskeleton
Bershadsky, A
Tuesday 14th July 2015, 14:30  15:30
We discuss here some aspects of local and global selforganization of the actomyosin cytoskeleton in the fibroblasttype cells. (1) Locally, the cytoplasm comprises a multinodal network formed by small asters of actin filaments nucleated by DAAM1 formin and stabilized by the actin crosslinking protein filamin A. The asters are connected with each other by myosin II, so that the entire system forms a contractile network responsible for the maintenance of the cell shape. (2) Observations of the assembly of myosinII filament arrays by structured illumination microscopy (SIM) revealed myosinII “stacks” formed by alignment in register of the myosinII bipolar filaments associated with actin fibers. In the cells spread over the planar substrate, the numerous myosin stacks apparently form the links between neighboring actin filament bundles (stressfibers or arcs), maintaining the organization of the actin cytoskeleton. (3) Globally, upon spreading on planar substrate s, cells develop chiral arrays of actin filament bundles. In fibroblasts confined to the circular adhesive islands, a radially symmetrical system of actin bundles, consisting of alphaactininenriched radial fibers (RFs) and myosinIIAenriched transverse fibers (TFs), evolved spontaneously into the chiral system as a result of the unidirectional tilting of all RFs accompanied by a tangential shift in the retrograde movement of TFs. The handedness of the chiral pattern is regulated by alphaactinin1. Experimental observations together with computational modeling, demonstrated how the interactions between RFs nucleated by formins and contractile TFs could result in the transition of the actin pattern from radial to chiral, leftright asymmetric organization. Thus, actin cytoskeleton selforganization provides builtin machinery that potentially allows cells to develop leftright asymmetry. Such actinbased mechanism could underlie the development of leftright asymmetry in tissues and embryos. Related Links:
http://labs.mbi.nus.edu.sg/abcd/index.html  Bershadsky's lab at Mechanobiology Institute, Singapore
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150715T19:09:22+01:00
4200
2029334
true
16x9
false

Selforganization and pattern formation in auxin flux
ucs_sms_1633792_2140734
http://sms.cam.ac.uk/media/2140734
Selforganization and pattern formation in auxin flux
Mazza, C (Universität Freiburg)
Friday 11th December 2015  14:15 to 15:00
Mon, 21 Dec 2015 11:28:24 +0000
Isaac Newton Institute
Mazza, C
f91bc81bf9cc30f84d3973d04c1e5920
4e6e02373be699772642cae046d09a24
36e131f52e44873d6947da62ad1f87fd
2c7103062ed567cffcd6ecd026fbed2c
Mazza, C (Universität Freiburg)
Friday 11th December 2015  14:15 to 15:00
Mazza, C (Universität Freiburg)
Friday 11th December 2015  14:15 to 15:00
Cambridge University
2454
http://sms.cam.ac.uk/media/2140734
Selforganization and pattern formation in auxin flux
Mazza, C (Universität Freiburg)
Friday 11th December 2015  14:15 to 15:00
The plant hormone auxin is instrumental for plant growth and morphogenesis. In the shoot apical meristem , the auxin flux is polarized through its interplay with PIN proteins. Concentration based mathematical models of the auxin flux permit to explain some aspects of phyllotaxis , where auxin accumulation points act as auxin sinks and correspond to primordia. Simulations show that these models can reproduce geometrically regular patterns like spirals in sunflowers or Fibonacci numbers. We propose a mathematical study of a related nonlinear o.d.e. using Markov chain theory. We will next consider a concurrent model which is based on the socalled flux hypothesis, and show that it can explain the selforganization of plant vascular systems.
Related Links
http://homeweb.unifr.ch/mazzac/pub/
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:28:24+00:00
2454
2140734
true
16x9
false

Selforganization of adipose tissue
ucs_sms_1633792_2078185
http://sms.cam.ac.uk/media/2078185
Selforganization of adipose tissue
Degond, P (Imperial College London)
Wednesday 16th September 2015  14:15 to 15:00
Tue, 29 Sep 2015 14:58:15 +0100
Isaac Newton Institute
Degond, P
43245a4dcd4becdcab609ce90539be88
17ea1772c79f40728114bce36e13ccec
b1f1a104d34302f9166c93cfc5a75bb6
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Degond, P (Imperial College London)
Wednesday 16th September 2015  14:15 to...
Degond, P (Imperial College London)
Wednesday 16th September 2015  14:15 to 15:00
Cambridge University
3125
http://sms.cam.ac.uk/media/2078185
Selforganization of adipose tissue
Degond, P (Imperial College London)
Wednesday 16th September 2015  14:15 to 15:00
One of the key functions of adipose tissue is to store energy for the needs of the organism. Dysfunction of adipose tissue results in conditions like obesity which affect an increasing number of people worldwide. In 2007, it was estimated that 50% of women and 65% of men in UK were overweight or obese. Yet, very few studies of how adipose tissue organizes during its development are available. The fat storing cells or adipocytes are organized in lobular structures separated by collagen fiber septa. In this work, we use an individualbased model to investigate scenarios for the formation of these lobules. We find that they could result from the combination of volume exclusion constraints between the adipocytes and confinement by the elasticity of the collagen fibers. In particular, the model shows that vasculature does not seem to notably influence the outcome of this morphogenesis process. This study suggests that the role of vaculature in adipogenesis could be more complex than originally thought.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T14:58:15+01:00
3125
2078185
true
16x9
false

Solving PDEs in domains with complex evolving morphology: Rothschild Visiting Fellow Lecture
ucs_sms_1633792_2078077
http://sms.cam.ac.uk/media/2078077
Solving PDEs in domains with complex evolving morphology: Rothschild Visiting Fellow Lecture
Elliott, C (University of Warwick)
Monday 14th September 2015  16:00 to 17:00
Tue, 29 Sep 2015 12:24:16 +0100
Isaac Newton Institute
Elliott, C
aaee6a522bbe48a2926d26a9ff1542dc
eb2d35e37a8be68c2658e5762e12b21e
457a2e865193d77e1c4724cf99f49264
Elliott, C (University of Warwick)
Monday 14th September 2015  16:00 to 17:00
Elliott, C (University of Warwick)
Monday 14th September 2015  16:00 to 17:00
Cambridge University
4320
http://sms.cam.ac.uk/media/2078077
Solving PDEs in domains with complex evolving morphology: Rothschild Visiting Fellow Lecture
Elliott, C (University of Warwick)
Monday 14th September 2015  16:00 to 17:00
Many physical models give rise to the need to solve partial differential equations in time dependent regions. The complex morphology of biological membranes and cells coupled with biophysical mathematical models present significant computational challenges as evidenced within the Newton Institute programme "Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation". In this talk we discuss the mathematical issues associated with the formulation of PDEs in time dependent domains in both flat and curved space. Here we are thinking of problems posed on time dependent ddimensional hypersurfaces Gamma(t) in R^{d+1}. The surface Gamma(t) may be the boundary of the bounded open bulk region Omega(t). In this setting we may also view Omega(t) as (d+1)dimensional submanifold in R^{d+2}. Using this observation we may develop a discretisation theory applicable to both surface and bulk equations. We will present an abstract framework for treating the theory of well posedness of solutions to abstract parabolic partial differential equations on evolving Hilbert spaces using generalised Bochner spaces. This theory is applicable to variational formulations of PDEs on evolving spatial domains including moving hypersurfaces. We formulate an appropriate time derivative on evolving spaces called the material derivative and define a weak material derivative in analogy with the usual time derivative in fixed domain problems; our setting is abstract and not restricted to evolving domains or surfaces. Then we show wellposedness to a certain class of parabolic PDEs under some assumptions on the parabolic operator and the data. Specifically, we study in turn a surface heat equation, an equation posed on a bulk domain, a novel coupled bulksurface system and an equation with a dynamic boundary condition. We give some background to applications in cell biology. We describe how the theory may be used in the development and numerical analysis of evolving surface finite element spaces which unifies the discrtetisation methodology for evolving surface and bulk equations. In order to have good discretisation one needs good meshes. We will indicate how geometric PDEs may be used to compute high quality meshes. We give some computational examples from cell biology involving the coupling of surface evolution to processes on the surface.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T12:24:16+01:00
4320
2078077
true
16x9
false

Streaming in Dd and Cellcell adhesions
ucs_sms_1633792_2078401
http://sms.cam.ac.uk/media/2078401
Streaming in Dd and Cellcell adhesions
Dallon, J (Brigham Young University)
Friday 18th September 2015  16:15 to 17:00
Tue, 29 Sep 2015 17:22:20 +0100
Isaac Newton Institute
Dallon, J
fe88c9fcb0afc7443ea81368dcb1bce3
cdba844ade71fafc4e1f4e6a7d7d6422
89b709e36ded8a928ecb49f9adac4524
50405ba7ed38eb6a62cde31cd3677065
Dallon, J (Brigham Young University)
Friday 18th September 2015  16:15 to...
Dallon, J (Brigham Young University)
Friday 18th September 2015  16:15 to 17:00
Cambridge University
3058
http://sms.cam.ac.uk/media/2078401
Streaming in Dd and Cellcell adhesions
Dallon, J (Brigham Young University)
Friday 18th September 2015  16:15 to 17:00
Results from two mathematical models will be discussed. In the first, contradictions between experiments and modeling in Dictyostelium discoideum will be addressed. Experiments suggest that streaming in early aggregation is dependent on localization of certain proteins (ACA) in the cell. Yet mathematical modeling seems to contradict this result. In the second model, the role of cadherin motion in the cell membrane will be studied to determine how it affects cellcell adhesion lengths. Using the immersed boundary method, the cell membrane and cortex is modeled. The model is used to help determine what role the actin cytoskeleton plays in cellcell adhesion.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T17:22:20+01:00
3058
2078401
true
16x9
false

Subdiffusion, Lévy walks and nonlinear fractional PDE's
ucs_sms_1633792_2059295
http://sms.cam.ac.uk/media/2059295
Subdiffusion, Lévy walks and nonlinear fractional PDE's
Fedotov, S (University of Manchester)
Tuesday 18 August 2015, 11:0012:00
Tue, 01 Sep 2015 10:45:32 +0100
Isaac Newton Institute
Fedotov, S
e625b1035be22757c5aae9410b979790
ebd4dbaa6514bdbca7194d14d9e04f19
1df3e9ffe1b615c101120d2d1d0f6869
ca1c42ad7d0b6db3dd56072c5a44ff38
Fedotov, S (University of Manchester)
Tuesday 18 August 2015, 11:0012:00
Fedotov, S (University of Manchester)
Tuesday 18 August 2015, 11:0012:00
Cambridge University
3141
http://sms.cam.ac.uk/media/2059295
Subdiffusion, Lévy walks and nonlinear fractional PDE's
Fedotov, S (University of Manchester)
Tuesday 18 August 2015, 11:0012:00
The talk will be concerned with the extension of the classical fractional PDE's for the nonlinear case involving interactions of Lévy walks and subdiffusive particles.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150901T10:45:32+01:00
3141
2059295
true
16x9
false

Surface finite element methods
ucs_sms_1633792_2078275
http://sms.cam.ac.uk/media/2078275
Surface finite element methods
Stinner, B (University of Warwick)
Thursday 17th September 2015  15:30 to 16:15
Tue, 29 Sep 2015 16:17:15 +0100
Isaac Newton Institute
Stinner, B
d9f8e22aa7125477a60d26386db23f2c
ec8126e89ec2e3b84a206c39038fa46e
d97cab8f68644f1825c56b11633c69b6
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Stinner, B (University of Warwick)
Thursday 17th September 2015  15:30 to...
Stinner, B (University of Warwick)
Thursday 17th September 2015  15:30 to 16:15
Cambridge University
2937
http://sms.cam.ac.uk/media/2078275
Surface finite element methods
Stinner, B (University of Warwick)
Thursday 17th September 2015  15:30 to 16:15
Coauthors: Charles Elliott (University of Warwick), Paola Pozzi (University of DuisburgEssen), Chandrasehkar Venkataraman (University of Sussex)
Complex phenomena such as moving cells may involve phenomena or processes on lower dimensional objects that separate compartments, phases, or other types of domains. Surface finite elements can provide a mean to approximate solutions to continuum models and, thus, after defining suitable objectives to compare with experimental data. In this context, we will report on new findings regarding the convergence analysis of schemes for simple coupled systems consisting of a geometric PDE for a curve and a diffusion equation on that curve. More sophistical systems of such a structure can be applied in cell biology where we exemplary look at the quantification of an approach to cell migration and, time permitting, focal adhesions and tethering of elastic membranes.
Related Links
http://homepages.warwick.ac.uk/staff/Bjorn.Stinner/preprints/Stinner_RSIF2012_prep.pdf  Description of the cell motility model
http://arxiv.org/abs/1311.7602  Quantification of the cell motility model
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T16:17:15+01:00
2937
2078275
true
16x9
false

Swarming Models with RepulsiveAttractive Effects: Pattern Stability
ucs_sms_1633792_2140597
http://sms.cam.ac.uk/media/2140597
Swarming Models with RepulsiveAttractive Effects: Pattern Stability
Carrillo, J A (Imperial College London)
Friday 11th December 2015  09:00 to 10:00
Mon, 21 Dec 2015 11:28:29 +0000
Isaac Newton Institute
Carrillo, J A
8a90d02921e2ee1d5c28bf3fcfd5b8f7
3f707cf922585a1de711173a078f3546
3939fe7084342d2c3b4f5dc29832f725
afa081bd15fb2caa4425f9015f2ae28e
Carrillo, J A (Imperial College London)
Friday 11th December 2015  09:00 to...
Carrillo, J A (Imperial College London)
Friday 11th December 2015  09:00 to 10:00
Cambridge University
3432
http://sms.cam.ac.uk/media/2140597
Swarming Models with RepulsiveAttractive Effects: Pattern Stability
Carrillo, J A (Imperial College London)
Friday 11th December 2015  09:00 to 10:00
I will present a survey of the main results about first and second order models of swarming where repulsion and attraction are modeled through pairwise potentials. We will mainly focus on the stability of the fascinating patterns that you get by random data particle simulations, flocks and mills, and their qualitative behavior.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T11:28:29+00:00
3432
2140597
true
16x9
false

Systems Biology Research at Microsoft
ucs_sms_1633792_2160730
http://sms.cam.ac.uk/media/2160730
Systems Biology Research at Microsoft
Dr Neil Dalchau (Microsoft Research)
Wednesday 9th Dec 2015, 14:30  15:00
Mon, 25 Jan 2016 14:30:01 +0000
Isaac Newton Institute
Dr Neil Dalchau
2a856015cc037fa5fd64c3938fef243d
524b52fdd83bc5d83f0e01360bd7f67c
764599833f2f7a3c147f3f0af5ffa2e4
47875b98b91b11b2ebe90c0edb6fddcf
Dr Neil Dalchau (Microsoft Research)
Wednesday 9th Dec 2015, 14:30  15:00
Dr Neil Dalchau (Microsoft Research)
Wednesday 9th Dec 2015, 14:30  15:00
Cambridge University
1768
http://sms.cam.ac.uk/media/2160730
Systems Biology Research at Microsoft
Dr Neil Dalchau (Microsoft Research)
Wednesday 9th Dec 2015, 14:30  15:00
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20160125T14:30:02+00:00
1768
2160730
true
16x9
false

The cell cortex is an excitable medium
ucs_sms_1633792_2078070
http://sms.cam.ac.uk/media/2078070
The cell cortex is an excitable medium
Goryachev, A (University of Edinburgh)
Monday 14th September 2015  14:15 to 15:00
Tue, 29 Sep 2015 10:34:50 +0100
Isaac Newton Institute
Goryachev, A
df039d8a8d9d5461738cd8349725ac1d
d30743e5a6d953f83f8e622c7a52c270
8723cd769c9fb6a880df1f211051644a
f2f4baa123226802671c345dd4a4c7d0
Goryachev, A (University of Edinburgh)
Monday 14th September 2015  14:15 to...
Goryachev, A (University of Edinburgh)
Monday 14th September 2015  14:15 to 15:00
Cambridge University
2566
http://sms.cam.ac.uk/media/2078070
The cell cortex is an excitable medium
Goryachev, A (University of Edinburgh)
Monday 14th September 2015  14:15 to 15:00
Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. We show that shortly after anaphase onset oocytes and embryonic cells of frogs and echinoderms exhibit cortical waves of Rho activity and Factin polymerization. The waves are modulated by cyclindependent kinase 1 (Cdk1) activity and require the Rho GEF (guanine nucleotide exchange factor), Ect2. Surprisingly, during wave propagation, while Rho activity elicits Factin assembly, Factin subsequently inactivates Rho. Experimental and modeling results show that waves represent excitable dynamics of a reaction diffusion system with Rho as the activator and Factin the inhibitor. We propose that cortical excitability explains fundamental features of cytokinesis including its cell cycle regulation.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T10:34:50+01:00
2566
2078070
true
16x9
false

The dynamic cytoskeleton
ucs_sms_1633792_2030499
http://sms.cam.ac.uk/media/2030499
The dynamic cytoskeleton
Windoffer, R (RWTH Aachen University)
Wednesday 15th July 2015, 13:30 to 14:45
Fri, 17 Jul 2015 18:33:13 +0100
Isaac Newton Institute
Windoffer, R
0e416ef35e997c2a518684c3d4800412
73c661574d5932b7ec1709a2c6a70c54
52c13682af1c0fd71e1593ecf92ebd8e
7635aeb4d39ba9d8e06deb00bdc4bf3d
Windoffer, R (RWTH Aachen University)
Wednesday 15th July 2015, 13:30 to 14:45...
Windoffer, R (RWTH Aachen University)
Wednesday 15th July 2015, 13:30 to 14:45
Cambridge University
4500
http://sms.cam.ac.uk/media/2030499
The dynamic cytoskeleton
Windoffer, R (RWTH Aachen University)
Wednesday 15th July 2015, 13:30 to 14:45
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150717T18:33:14+01:00
4500
2030499
true
16x9
false

The Filament Based Lamellipodium Model: a continuum model derived from actin filament dynamics
ucs_sms_1633792_2077030
http://sms.cam.ac.uk/media/2077030
The Filament Based Lamellipodium Model: a continuum model derived from actin filament dynamics
Schmeiser, C (Universität Wien)
Monday 14th September 2015  13:30 to 14:15
Tue, 29 Sep 2015 10:43:29 +0100
Isaac Newton Institute
Schmeiser, C
bb0db58cc1a8da90d5be702fff2a8ec6
3a7654f5701aa5e7f6db0765f4684cdf
cba40d198f82280d3452ff61237ede60
9c2d69c5fa2181d493d2e7a0296e27c4
Schmeiser, C (Universität Wien)
Monday 14th September 2015  13:30 to 14:15
Schmeiser, C (Universität Wien)
Monday 14th September 2015  13:30 to 14:15
Cambridge University
3292
http://sms.cam.ac.uk/media/2077030
The Filament Based Lamellipodium Model: a continuum model derived from actin filament dynamics
Schmeiser, C (Universität Wien)
Monday 14th September 2015  13:30 to 14:15
Coauthors: Angelika Manhart (Univ. of Vienna), Dietmar Oelz (New York Univ.), Nikolaos Sfakianakis (Univ. Mainz), J. Vic Small (Inst. f. Molecular Biotechn. Austria)
The lamellipodium is a flat cell protrusion functioning as a motility organelle for cells on flat substrates. It is a very dynamic structure mainly consisting of a network of filaments of polymerized actin. The Filament Based Lamellipodium Model is a twodimensional, twophase, anisotropic continuum model for the dynamics of this network, which has been developed over the past 8 years. It has been derived from a microscopic description based on the dynamics and interaction of individual filaments. Some aspects of the derivation of the model, of its analysis, and of its numerical solution will be presented, together with some recent simulation results.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T10:43:29+01:00
3292
2077030
true
16x9
false

The mechanobiology of adipocytes
ucs_sms_1633792_2108184
http://sms.cam.ac.uk/media/2108184
The mechanobiology of adipocytes
Gefen, A (Tel Aviv University)
Tuesday 3rd November 2015  10:00 to 11:00
Wed, 11 Nov 2015 11:05:00 +0000
Isaac Newton Institute
Gefen, A
687d536a62ad132ebe8b7d6f688d4e06
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Gefen, A (Tel Aviv University)
Tuesday 3rd November 2015  10:00 to 11:00
Gefen, A (Tel Aviv University)
Tuesday 3rd November 2015  10:00 to 11:00
Cambridge University
3529
http://sms.cam.ac.uk/media/2108184
The mechanobiology of adipocytes
Gefen, A (Tel Aviv University)
Tuesday 3rd November 2015  10:00 to 11:00
We recently discovered that fat cells (adipocytes) are mechanosensitive and responsive to sustained mechanical loading. This discovery is fundamentally important for understanding the longterm effects of a sedentary life style (i.e. prolonged sitting and lying periods), given that such a lifestyle predominantly involves static mechanical loads acting upon and within the cells. Our celllevel biomechanical research approach revealed accelerated adipogenesis (production of triglycerides) in cells subjected to sustained large deformations. Specifically, we have developed tissueengineered threedimensional (3D) fat cultures in order to determine their mechanical behavior under large physiological deformations. We have further investigated the mechanical behavior of maturing adipocytes in vitro and in silico, to understand the biomechanical cellcell interactions that potentially lead to increase in adipogenesis and eventually, gain of additional fat mass. We showed how these cellcell biomechanical interactions trigger molecular signaling pathways such as the MAPK/ERK, which activate the adipogenesis. Additional novel findings from our group, at the individual adipocyte celllevel, demonstrated an increase in cell stiffness with accumulation of intracytoplasmic lipid droplets (LDs) using both atomic force and interferometric phase microscopies. These results were used together to develop 3D computational finite element cell modeling of adipocytes, for simulating the structural, large deformation behavior of the maturing adipocytes. Based on our modeling framework, we found that external loads induced localized large strains in the plasma membrane of the cells, which had maximum values over the LDs, thereby providing an explanation regarding how mechanical stimulation accelerated the adipogenesis. The above experimental model systems of cultured adipocytes that were developed in our laboratory facilitated development of multiscale in silico models of adipocytes embedded in an extracellular matrix. These computational models provided the first evidence that sustained deformations in weightbearing adipose tissues, as in a sedentary lifestyle, can indeed activate a vicious cycle that takes the form of a positive feedback loop promoting "en mass" adipogenesis. This leads to a viscous cycle at the tissuescale, which eventually increases the total mass of fat tissues. Our published studies overall provide the explanation regarding how maturing adipocytes deform each other in weightbearing fat tissues, in a spiral that contributes to the adipogenesis at the cellscale, and then to gain of fat mass, overweight and obesity at the tissue and body scales.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151111T11:05:00+00:00
3529
2108184
true
16x9
false

The structural integrity of cells under sustained mechanical deformations: The key for understanding pressure ulcers
ucs_sms_1633792_2140259
http://sms.cam.ac.uk/media/2140259
The structural integrity of cells under sustained mechanical deformations: The key for understanding pressure ulcers
Gefen, A (Tel Aviv University)
Monday 7th December 2015  14:15 to 15:00
Mon, 21 Dec 2015 10:21:23 +0000
Isaac Newton Institute
Gefen, A
5d06c5d1516a19b9670144fc6818fb74
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Gefen, A (Tel Aviv University)
Monday 7th December 2015  14:15 to 15:00
Gefen, A (Tel Aviv University)
Monday 7th December 2015  14:15 to 15:00
Cambridge University
3116
http://sms.cam.ac.uk/media/2140259
The structural integrity of cells under sustained mechanical deformations: The key for understanding pressure ulcers
Gefen, A (Tel Aviv University)
Monday 7th December 2015  14:15 to 15:00
Sustained internal mechanical loads in tissues which develop during immobile weightbearing postures such as while in bed or in a chair were identified as a fundamental cause for the onset and progression of pressure ulcers (PUs), particularly of the deep tissue injury (DTI) type. The sustained loading may compromise tissue viability either directly, by distorting cell shapes, or indirectly, by distorting the vasculature or lymphatic networks or, at the microscale, by distorting cellular organelles involved in regulating transport, e.g. the plasma membrane (PM). This talk will review our record of published research concerning the effects of sustained deformations across the different hierarchical scales: tissuescale [cm], mesoscale [mm] and cellscale [μm], with a focus on how sustained bodyweight loads eventually compromise homeostasis and cell viability. The evolution of our work to test our central hypothesis will be shown, specifically, that macroscopic tissue defo rmations translate to celllevel deformations and in particular, to localized tensile strains in the plasma membrane (PM) of cells. These localized PM stretches increase the permeability of the PM which, over time, could disrupt vital transport processes such as the function of ion channels, endocytosis and exocytosis. Viability of tissues exposed to sustained loading in the context of pressure ulcer development should therefore be investigated in all dimensional scales, from the macro to micro, and in particular at a cell scale, in order to provide complete understanding of the aetiology of PUs and DTIs and for identifying individuals for whom and conditions at which the susceptibility to these injuries might be greater. Emerging relevant methods of cell permeability quantification and modeling such as multiscale and multiphysics modeling will be highlighted, as they contribute substantially to the aetiological research in this field.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:21:23+00:00
3116
2140259
true
16x9
false

Theoretical model for persistent and oscillatory cell motility
ucs_sms_1633792_2059317
http://sms.cam.ac.uk/media/2059317
Theoretical model for persistent and oscillatory cell motility
Gov, N (Weizmann Institute of Science)
Wednesday 26 August 2015, 11:0012:30
Tue, 01 Sep 2015 11:19:11 +0100
Isaac Newton Institute
Gov, N
fbb6efc255739697aeed7cbb3e28415f
f90c56d46e3e358c5f44b89d6f7c79ca
a984954947e03f99bfbce6d04b50d34e
aeb0437a6668d3bf059ece7db09b151f
Gov, N (Weizmann Institute of Science)
Wednesday 26 August 2015, 11:0012:30
Gov, N (Weizmann Institute of Science)
Wednesday 26 August 2015, 11:0012:30
Cambridge University
4500
http://sms.cam.ac.uk/media/2059317
Theoretical model for persistent and oscillatory cell motility
Gov, N (Weizmann Institute of Science)
Wednesday 26 August 2015, 11:0012:30
Cell movement has essential functions in development, immunity and cancer. Various cell migration patterns have been reported, such as Brownian motion, intermittent and persistent randomwalks, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns. Recent extensions of this model describe the oscillatory motion of dendritic cells, which compare very well with experiments. Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence Maiuri P, Rupprecht JF, Wieser S, Ruprecht V, Benichou O, Carpi N, Coppey M, De Beco S, Gov N, Heisenberg CP, Crespo CL, Lautenschlaeger F, Le Berre M, LennonDumenil AM, Raab M, Thiam HR, Piel M, Sixt M, Voituriez R, Cell 161 , 374386 (2015)
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150901T11:19:11+01:00
4500
2059317
true
16x9
false

Turing bifurcation, wavepinning or localised patterns for cell polarity formation; three sides of the same coin?
ucs_sms_1633792_2140266
http://sms.cam.ac.uk/media/2140266
Turing bifurcation, wavepinning or localised patterns for cell polarity formation; three sides of the same coin?
Champneys, A (University of Bristol)
Tuesday 8th December 2015  09:00 to 10:00
Mon, 21 Dec 2015 10:28:03 +0000
Isaac Newton Institute
Champneys, A
0edc8270f84fae7b2acc60cc1a3cff78
451f182365334c2c276edbfeda38327f
efe0125a0fc3964ef85d093c92803344
19bf0e0025f7ec8448a11a3845b4d709
Champneys, A (University of Bristol)
Tuesday 8th December 2015  09:00 to 10:00
Champneys, A (University of Bristol)
Tuesday 8th December 2015  09:00 to 10:00
Cambridge University
3600
http://sms.cam.ac.uk/media/2140266
Turing bifurcation, wavepinning or localised patterns for cell polarity formation; three sides of the same coin?
Champneys, A (University of Bristol)
Tuesday 8th December 2015  09:00 to 10:00
In this talk I shall present recent work in collaboration with students Nicolas Verschuren and with Victor Brena motivated by problems of cellular level polarity formation motivated by a range of problems in plant biology. After reviewing some existing theories based on reactiondiffusion modelling, I will present some work on plant root hair formation in Arabidopsis in collaboration with Claire Grierson. By modelling the kinetics of the plant rho proteins, or ROPs, it will be argued that the key mechanism can be explained by the formation of a localised patch, which arises due to the presence of a subcritical Turing bifurcation and the recent theory of socalled homoclinic snaking. To see what happens in wild type, one needs to include spatial gradients, such that the dynamics of the patch can be explained asymptotically with the help of Michael Ward's semistrong analysis technique. The mechanism is contrasted with that of the recent theory of wave pinning in massconservative reactiondiffusion equations. It is argued that small source and loss terms are biologically motivated by actions of the nucleus controlling the process and by proteins being recycled as symmetrybreaking takes hold. A new study is then undertaken of what happens under introduction of small source and loss terms to a canonical wavepinning model. It is shown that localised patterns develop into snakes in one limit and in other limit develop into pinned fronts. A new asymptotic analysis shows how front selection occurs in the limit that the source and loss terms tend to zero.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20151221T10:28:03+00:00
3600
2140266
true
16x9
false

What’s lumen got to do with it? Mechanics and transport in lung morphogenesis
ucs_sms_1633792_2078230
http://sms.cam.ac.uk/media/2078230
What’s lumen got to do with it? Mechanics and transport in lung morphogenesis
Lubkin, S (North Carolina State University)
Thursday 17th September 2015  13:30 to 14:15
Tue, 29 Sep 2015 15:20:05 +0100
Isaac Newton Institute
Lubkin, S
50ce7fc94bd0214ff28c0661b1690f78
d0ebbffc16a1714cde5aec735ed51317
5451f03ce2f2082b73caa52c56066ae6
cf8df47b2aa989cb3180599902c455e8
Lubkin, S (North Carolina State University)
Thursday 17th September 2015 ...
Lubkin, S (North Carolina State University)
Thursday 17th September 2015  13:30 to 14:15
Cambridge University
2991
http://sms.cam.ac.uk/media/2078230
What’s lumen got to do with it? Mechanics and transport in lung morphogenesis
Lubkin, S (North Carolina State University)
Thursday 17th September 2015  13:30 to 14:15
Mammalian lung morphology is well optimized for efficient bulk transport of gases, yet most lung morphogenesis occurs prenatally, when the lung is filled with liquid  and at birth it is immediately ready to function when filled with gas. Lung morphogenesis is regulated by numerous mechanical inputs including fluid secretion, fetal breathing movements, and peristalsis. We generally understand which of these broad mechanisms apply, and whether they increase or decrease overall size and/or branching. However, we do not have a clear understanding of the intermediate mechanisms actuating the morphogenetic control. We have studied this aspect of lung morphogenesis from several angles using mathematical/mechanical/transport models tailored to specific questions. How does lumen pressure interact with different locations and tissues in the lung? Is static pressure equivalent to dynamic pressure? Of the many plausible cellular mechanisms of mechanosensing in the prenatal lung, which a re compatible with the actual mechanical situation? We will present our models and results which suggest that some hypothesized intermediate mechanisms are not as plausible as they at first seem.
Vincenzo Abete
http://sms.cam.ac.uk/person/va281
20150929T15:20:05+01:00
2991
2078230
true
16x9
false
1633792